| Title |
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The effect of antagonism of adenosine A1 receptor against ischemia and reperfusion injury of the liver
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| Creator |
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| Accessrights |
open access |
| Subject |
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Other
en
liver
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Other
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ischemia and reperfusion injury
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Other
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adenosine
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Other
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adenosine A1 receptor antagonist
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Other
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KW3902
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Other
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dog
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NDC
464.657
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| Description |
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Abstract
en
Background: Adenosine is known to exert protective roles in hepatic ischemia and reperfusion injury, while all adenosine receptors do not play the cytoprotective roles. We have tested our hypothesis that blockage of adenosine binding to A1 receptor by its antagonist, KW3902 [8-(noradamantan-3-yl)-1,3-dipropylxanthine] attenuates hepatic ischemia-reperfusion injury. Methods: Adult female beagle dogs underwent a 2 h total hepatic vascular exclusion (THVE) with a venovenous bypass. Nontreated animals that underwent THVE with a venovenous bypass alone were used as the control (Group CT, n = 6). KW3902 was given to the animals by continuous intraportal infusion for 60 min before ischemia at a dose of 1μg/kg/min (Group KW, n = 6). Two wk survival, hemodynamics, hepatic tissue blood flow (HTBF), liver function, energy metabolism, cAMP concentration, and histopathological findings were studied. Results: Two wk animal survival was significantly improved in group KW compared with that in group CT (group CT: 16.7% versus group KW: 83.3%). HTBF, liver function, and hepatic adenine nucleotide concentration were remarkably better in group KW than group CT. In addition, cAMP concentration in group KW was maintained significantly higher than group CT. Histopathological examination revealed preservation of hepatic architecture and suppression of neutrophil infiltration into hepatic tissue in group KW. Conclusion: Administration of adenosine A1 receptor antagonist before ischemia attenuates hepatic ischemia-reperfusion injury. To elicit the beneficial effect of adenosine against ischemia and reperfusion injury of the liver, it is important to oppose adenosine A1 receptor activation.
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| Publisher |
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Elsevier
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
AM |
| Identifier |
HDL
http://hdl.handle.net/2115/22558
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| Relation |
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URI
http://www.sciencedirect.com/science/journal/00224804
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isVersionOf
DOI
https://doi.org/10.1016/j.jss.2006.09.021
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PMID
17336335
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| Journal |
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PISSN
0022-4804
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EISSN
1095-8673
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en
Journal of Surgical Research
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Volume Number139
Issue Number1
Page Start7
Page End14
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| File |
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| Oaidate |
2023-07-26 |
