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Title
  • en Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma
Creator
    • en Mega, Seiji
    • en Miyamoto, Masaki
    • en Li, Li
    • en Kadoya, Masatoshi
    • en Takahashi, Ryo
    • en Hase, Ryunosuke
    • en Kaneko, Hiroyuki
    • en Kawarada, You
    • en Itoh, Tomoo
    • en Morikawa, Toshiaki
Accessrights open access
Rights
  • en The definitive version is available at www.blackwell-synergy.com
Subject
  • Other en survivin
  • Other en esophageal squamous cell carcinoma
  • Other en immunohistochemistry
  • Other en carcinogenesis
  • Other en prognosis
  • NDC 494.5
Description
  • Abstract en Despite advances in the treatment of esophageal carcinoma, the prognosis for this disease remains poor. Therefore, it is important to obtain a better understanding of the molecular basis of esophageal carcinogenesis. The purpose of this study was to clarify the roles of survivin in esophageal squamous cell carcinoma (ESCC). One hundred 22 ESCC surgical specimens resected from 1989 to 1999 were examined. Survivin expression was assessed by immunohistochemistry. Tumor cells were considered survivin-positive if the immunoreactivity was confined to the nucleus, and a scoring method was applied. Survivin-positive immunostaining was detected in 68 patients (56%). There was a significant association between survivin expression and pN (P = 0.0472). Moreover, the overall survival rate was worse in patients with survivin-positive tumors than in patients with survivin-negative tumors (P = 0.0189). The overexpression of survivin was associated with the overall survival rate and poor prognosis in patients with ESCC. Survivin may be targeted during cancer therapy because of its selective expression in malignant tissue.
Publisher en Blackwell Publishing
Date
    Issued2006-10
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/30152
Relation
  • isVersionOf DOI https://doi.org/10.1111/j.1442-2050.2006.00604.x
  • PMID 16984532
Journal
    • PISSN 1120-8694
    • EISSN 1442-2050
      • en Diseases of the Esophagus
      • Volume Number19 Issue Number5 Page Start355 Page End359
File
    • fulltext DOE19-5.pdf
    • 470.4 KB (application/pdf)
      • Issued2006-10
Oaidate 2023-07-26