| Title |
-
en
Testicular toxicity of profenofos in matured male rats
|
| Creator |
|
| Accessrights |
open access |
| Rights |
-
en
The original publication is available at www.springerlink.com
|
| Subject |
-
Other
en
profenofos
-
Other
en
cytochrome P450
-
Other
en
testosterone
-
Other
en
testis
-
NDC
649
|
| Description |
-
Abstract
en
To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined, which revealed testicular destruction and degeneration represented by a layer of columnar epithelium, oedematous changes surrounding the seminiferous tubules besides vacuolated spermatogonial cells and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity.
|
| Publisher |
en
Springer
|
| Date |
|
| Language |
|
| Resource Type |
journal article |
| Version Type |
AM |
| Identifier |
HDL
http://hdl.handle.net/2115/32319
|
| Relation |
-
URI
http://www.springerlink.com
-
isVersionOf
DOI
https://doi.org/10.1007/s00204-007-0217-2
-
PMID
17569032
|
| Journal |
-
-
PISSN
0340-5761
-
EISSN
1432-0738
-
en
Archives of Toxicology
-
Volume Number81
Issue Number12
Page Start875
Page End881
|
| File |
|
| Oaidate |
2023-07-26 |
