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Title
  • en Memory and Decision Making in the Frontal Cortex during Visual Motion Processing for Smooth Pursuit Eye Movements
Creator
Accessrights open access
Subject
  • Other en Frontal cortex
  • Other en Supplementary eye fields
  • Other en Smooth pursuit
  • Other en Visual motion
  • Other en Memory
  • Other en Decision-making
  • Other en Movement preparation, Monkey
  • NDC 491
Description
  • Abstract en Cortical motor areas are thought to contribute "higher-order processing" but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons did not distinguish activity associated with the preparation for pursuit from discharge related to processing or memory of the target motion signals. Using a new, memory-based task, which was designed to separate these components, we show that the SEF contains signals coding retinal image-slip-velocity, memory and assessment of visual motion-direction, the decision of whether or not to pursue, and the preparation for pursuit eye movements. Bilateral muscimol injection into SEF resulted in directional errors in smooth pursuit, errors of whether or not to pursue, and impairment of initial correct eye movements. These results suggest an important role for the SEF in memory and assessment of visual motion-direction and the programming of appropriate pursuit eye movements.
Publisher en Cell Press
Date
    Issued2009-06-11
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/38756
Relation
  • isVersionOf DOI https://doi.org/10.1016/j.neuron.2009.05.010
Journal
    • PISSN 0896-6273
      • en Neuron
      • Volume Number62 Issue Number5 Page Start717 Page End732
File
Oaidate 2023-07-26