Back

Title
  • en Regioselective synthesis of β-fluoro-α,β-unsaturated ketones by the reaction of β-diketones with DFMBA
Creator
    • en Sano, Keisuke
    • en Fukuhara, Tsuyoshi
Accessrights open access
Subject
  • Other en β-Fluoro-α,β-unsaturated ketone
  • Other en β-Diketone
  • Other en N,N-Diethyl-α,α-difluoro-m-methylbenzylamine
  • Other en Deoxyfluorination
  • Other en Regioselective
  • NDC 435
Description
  • Abstract en The deoxyfluorination reaction of β-diketones with N,N-diethyl-α,α-difluoro-m-methylbenzylamine (DFMBA) gave β-fluoro-α,β-unsaturated ketones in good yields. The reaction proceeded regioselectively, and only one regioisomer was obtained from the unsymmetrical 1-aryl-1,3-diketones. The reaction is applicable to diketones with a trifluoromethyl group, obtaining good yields of 3,4,4,4-tetrafluorobutenones. We used the resulting β-filuoro-α,β-unsaturated ketones for the reaction with lithium dialkyl cuprates.
Publisher en Elsevier B.V.
Date
    Issued2009-08
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/39135
Relation
  • isVersionOf DOI https://doi.org/10.1016/j.jfluchem.2009.05.009
Journal
    • PISSN 0022-1139
      • en Journal of Fluorine Chemistry
      • Volume Number130 Issue Number8 Page Start708 Page End713
File
Oaidate 2023-07-26