Title |
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BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation
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Alternative |
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Physical and functional interactions between BS69 and LMP1/CTAR1
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Creator |
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Accessrights |
open access |
Subject |
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Other
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BS69
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Other
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EBV
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Other
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LMP1
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Other
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TRAF3
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Other
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NF-κB
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Other
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transcription
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NDC
464
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Description |
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Abstract
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Epstein-Barr virus latent membrane protein 1 (LMP1) activates NF-κB signaling pathways through two C-terminal regions, CTAR1 and CTAR2. Previous studies have demonstrated that BS69, a multidomain cellular protein, regulates LMP1/CTAR2-mediated NF-κB activation by interfering with the complex formation between TRADD and LMP1/CTAR2. Here, we found that BS69 directly interacted with the LMP1/CTAR1 domain and regulated LMP1/CTAR1-mediated NF-κB activation and subsequent IL-6 production. Regarding the mechanisms involved, we found that BS69 directly interacted with TRAF3, a negative regulator of NF-κB activation. Furthermore, small-interfering RNA-mediated knockdown experiments revealed that TRAF3 was involved in the BS69-mediated suppression of LMP1/CTAR1-induced NF-κB activation.
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Publisher |
en
Elsevier
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Date |
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Language |
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Resource Type |
journal article |
Version Type |
AM |
Identifier |
HDL
http://hdl.handle.net/2115/42639
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Relation |
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isVersionOf
DOI
https://doi.org/10.1016/j.febslet.2010.01.060
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PMID
20138174
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Journal |
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PISSN
0014-5793
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NCID
AA00642943
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en
FEBS Letters
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Volume Number584
Issue Number5
Page Start865
Page End872
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File |
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Oaidate |
2023-07-26 |