Title |
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Selective mono-acylation of 1,2-and 1,3-diols using (α,α-difluoroalkyl)amines
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Creator |
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Accessrights |
open access |
Subject |
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Other
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N,N-Diethyl-α,α-difluorobenzylamine
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Other
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Mono-benzoylation
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Other
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Diols
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Other
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Cyclic amide acetal
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NDC
431
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Description |
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Abstract
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In the reaction of N,N-diethyl-α,α-difluorobenzylamine (DFBA) with 1,2- or 1,3-diols, selective mono-benzoylation occurs to afford mono-esters of the diols in good yield. The reaction is completed under mild conditions in a short reaction time. Further, prim-, sec-, and tert-diols and catechol can be converted to the corresponding mono-benzoates. DFBA is used for the protection of the hydroxy group in sugars. The selective mono-nicotinylation, formylation and pivaloylation of diols are also performed by using the corresponding difluoroalkylamines.
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Publisher |
en
Elsevier
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Date |
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Language |
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Resource Type |
journal article |
Version Type |
AM |
Identifier |
HDL
http://hdl.handle.net/2115/44125
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Relation |
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isVersionOf
DOI
https://doi.org/10.1016/j.tet.2010.08.029
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Journal |
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Tetrahedron
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Volume Number66
Issue Number40
Page Start7939
Page End7945
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File |
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Oaidate |
2023-07-26 |