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Title
  • en Selective mono-acylation of 1,2-and 1,3-diols using (α,α-difluoroalkyl)amines
Creator
Accessrights open access
Subject
  • Other en N,N-Diethyl-α,α-difluorobenzylamine
  • Other en Mono-benzoylation
  • Other en Diols
  • Other en Cyclic amide acetal
  • NDC 431
Description
  • Abstract en In the reaction of N,N-diethyl-α,α-difluorobenzylamine (DFBA) with 1,2- or 1,3-diols, selective mono-benzoylation occurs to afford mono-esters of the diols in good yield. The reaction is completed under mild conditions in a short reaction time. Further, prim-, sec-, and tert-diols and catechol can be converted to the corresponding mono-benzoates. DFBA is used for the protection of the hydroxy group in sugars. The selective mono-nicotinylation, formylation and pivaloylation of diols are also performed by using the corresponding difluoroalkylamines.
Publisher en Elsevier
Date
    Issued2010-10-02
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/44125
Relation
  • isVersionOf DOI https://doi.org/10.1016/j.tet.2010.08.029
Journal
    • PISSN 0040-4020
      • en Tetrahedron
      • Volume Number66 Issue Number40 Page Start7939 Page End7945
File
Oaidate 2023-07-26