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Title
  • en High Prevalence of Multiple Human Papillomavirus Infection in Japanese Patients with Invasive Uterine Cervical Cancer
Creator
Accessrights open access
Rights
  • en Copyright © 2011 S. Karger AG, Basel
Subject
  • Other en Human papillomavirus, multiple infection
  • Other en Cervix uteri
  • Other en Array technology
  • NDC 495
Description
  • Abstract en Objective: Multiple human papillomavirus (HPV) infection of the uterine cervix has been suggested as a risk factor for persistent HPV infection, resulting in the development of invasive cervical cancer. The aim of this study was to reveal the actual state of multiple HPV infection in Japanese patients with invasive cervical cancer. Methods: Freshly-frozen 60 invasive cervical cancer tissues were examined for genotyping of HPV. The presence of HPV genotypes in the cancer tissues was determined by an HPV-DNA array, which can discriminate 25 different HPV genotypes with high sensitivity and specificity. Results: Among 60 samples, 59 (96.7%) were positive for HPV. The three common genotypes were HPV-16 (83.3%), HPV-18 (45.0%) and HPV-52 (28.3%). Multiple HPV infection was observed in 47 of 60 samples (78.3%), in which 42 cases were infected with more than one high-risk genotypes (70.0%). The multiple high-risk HPV infection was significantly more prevalent in patients below 40 years old (14/15, 93.3%) than in patients 40 years and over (28/45, 62.2%). Conclusion: The HPV-DNA array is the preferable method to detect HPV genotypes. Multiple HPV infection in Japanese patients with invasive cervical cancer seemed to be more frequent than reported in the literature.
Publisher en Karger
Date
    Issued2011-07
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/46895
Relation
  • isVersionOf DOI https://doi.org/10.1159/000326770
  • PMID 21778789
Journal
    • PISSN 1015-2008
      • en Pathobiology
      • Volume Number78 Issue Number4 Page Start220 Page End226
File
Oaidate 2023-07-26