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Title
  • en Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering
Creator
    • en Trirongjitmoah, Suchin
    • en Sakurai, Toshihiro
    • en Iinaga, Kazuya
    • en Chiba, Hitoshi
Accessrights open access
Rights
  • en ©2010 Optical Society of America
Subject
  • NDC 425
Description
  • Abstract en Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-of-care testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements.
Publisher en Optical Society of America
Date
    Issued2010-03-15
Language
  • eng
Resource Type journal article
Version Type VoR
Identifier HDL http://hdl.handle.net/2115/47804
Relation
  • isIdenticalTo DOI https://doi.org/10.1364/OE.18.006315
  • PMID 20389654
Journal
    • EISSN 1094-4087
      • en Optics Express
      • Volume Number18 Issue Number6 Page Start6315 Page End6326
File
Oaidate 2023-07-26