Title |
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Effects of parabens on apoptosis induced by serum-free medium.
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Creator |
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Accessrights |
open access |
Rights |
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This is an Author's Accepted Manuscript of an article published in Journal of Environmental Science and Health, Part B Pesticides, Food Contaminants, and Agricultural Wastes, Vol. 47, Iss. 3, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/03601234.2012.634341.
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Subject |
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Other
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PC12 cell
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Other
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endocrine disrupter
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Other
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food additives
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Other
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apoptotic factors
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Other
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methylparaben
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Other
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butylparaben
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NDC
498
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Description |
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Abstract
en
Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation in PC12 cells were investigated. In addition, apoptosis-related factors were assayed. As results, a tendency toward enhancement of apoptosis was observed in the cells cultured in the serum-free medium with methylparaben, and this tendency was suggested to be related to the contents of BAD, a pro-apoptotic protein. Butylparaben did not show any tendency to enhance apoptosis.
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Publisher |
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Taylor & Francis
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Date |
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Language |
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Resource Type |
journal article |
Version Type |
AM |
Identifier |
HDL
http://hdl.handle.net/2115/52989
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Relation |
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isVersionOf
DOI
https://doi.org/10.1080/03601234.2012.634341
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PMID
22375591
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Journal |
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PISSN
0360-1234
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EISSN
1532-4109
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NCID
AA00697424
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en
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
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Volume Number47
Issue Number3
Page Start196
Page End204
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File |
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Oaidate |
2023-07-26 |