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Title
  • en Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger
Creator
    • en Tanimura, Kazuhide
    • en Shimizu, Masato
    • en Matsuhashi, Megumi
    • en Fukae, Jun
    • en Kon, Yujiro
    • en Hagiwara, Hiromi
    • en Narita, Akihiro
    • en Aoki, Yuko
    • en Kosaka, Naoki
Accessrights open access
Rights
  • en The final publication is available at www.springerlink.com
Subject
  • Other en Anti-interleukin 6 receptor antibody
  • Other en Rheumatoid arthritis
  • Other en Quantitative analysis
  • Other en Magnetic resonance imaging
  • Other en Power Doppler ultrasonography
  • NDC 492
Description
  • Abstract en Objectives: To compare quantitative magnetic resonance imaging (MRI) and power Doppler ultrasonography (PDUS) with conventional measures of disease activity in rheumatoid arthritis (RA) patients with the anti-interleukin 6 (anti-IL 6) receptor tocilizumab in terms of responsiveness at a few months to disease activity and ability to predict structural damage at 1 year. Methods: A cohort of patients with RA (n = 29) was evaluated clinically including disease activity score 28 (DAS28) and by semiquantitative (SQ-) and quantitative (Q-) PDUS (bilateral metacarpophalangeal joints) and MRI (one hand and wrist) at initiation of treatment with anti-IL 6 receptor antibody agents and after 2 and 5 months. Conventional radiography for both hands and wrists was performed at baseline and at 12 months. Responsiveness was assessed by standardized response means (SRM). Areas under the curve (AUC) for measures at baseline, 2 and 5 months were correlated with structural damage at one year. Results: Among the laboratory and clinical parameters, DAS28-ESR was the most responsive with a large effect size of SRM. Structural damage progressions for radiography and MR erosion were correlated with AUC of MR bone erosion and Q-PDUS, respectively. Conclusions: In the evaluation of disease activity in RA patients in the first few months after starting anti-IL 6 receptor antibody tocilizumab treatment, the semi-quantitative MR bone erosion score of the hand and quantitative value for power Doppler signal in the finger joint were both responsive and predictive of structural damage progression at 1 year.
Publisher en Springer Berlin / Heidelberg
Date
    Issued2011-06
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/49371
Relation
  • isVersionOf DOI https://doi.org/10.1007/s00256-010-1064-4
  • PMID 21076827
Journal
    • PISSN 0364-2348
    • EISSN 1432-2161
      • en Skeletal Radiology
      • Volume Number40 Issue Number6 Page Start745 Page End755
File
Oaidate 2023-07-26