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Title	en Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex
Creator	en Tsutsui-Kimura, Iku en Ohmura, Yu en Izumi, Takeshi NRID 1000060312360 en Kumamoto, Haruko en Yamaguchi, Taku en Yoshida, Takayuki en Yoshioka, Mitsuhiro NRID 1000040182729
Accessrights	open access
Rights	en The original publication is available at www.springerlink.com
Subject	Other en Response inhibition Other en Inhibitory control Other en Ventromedial prefrontal cortex Other en Suicide Other en Addiction Other en Five-choice serial reaction time task NDC 493
Description	Abstract en Rationale: Elevated impulsivity is often observed in patients with depression. We recently found that milnacipran, an antidepressant and a serotonin/noradrenaline reuptake inhibitor, could enhance impulse control in rats. However, the neural mechanisms underlying the effects of milnacipran on impulsive action remain unclear. Milnacipran increases not only extracellular serotonin and noradrenaline but also dopamine specifically in the medial prefrontal cortex, which is one of brain regions responsible for impulsive action. Objectives: Our goal was to identify whether D1-like and/or D2-like receptors in the infralimbic cortex (IL), the ventral portion of the medial prefrontal cortex, mediates the milnacipran-enhanced impulse control in a three-choice serial reaction time task. Methods: The rats were bilaterally injected with SCH23390, a selective D1-like receptor antagonist (0.3 or 3 ng/side) or eticlopride, a selective D2-like receptor antagonist (0.3 or 1 μg/side) into the IL after acute intraperitoneal administration of milnacipran (10 mg/kg). Results: Intra-IL SCH23390 injections reversed the milnacipran-enhanced impulse control, whereas injections of eticlopride into the IL failed to block the effects of milnacipran on impulsive action. Conclusions: This is the first report that demonstrates a critical role for D1-like receptors of the IL in milnacipran-enhanced control of impulsive action.
Publisher	en Springer-Verlag
Date	Issued2013-01
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/54108
Relation	isVersionOf DOI https://doi.org/10.1007/s00213-012-2835-5 PMID 22892727
Journal	PISSN 0033-3158 en Psychopharmacology Volume Number225 Issue Number2 Page Start495 Page End504
File	fulltext Psy225-2_495-504.pdf 555.57 KB (application/pdf) Issued2013-01 fulltext Supplementary_Material.docx 231.64 KB (application/vnd.openxmlformats-officedocument.wordprocessingml.document) Issued2013-01
Oaidate	2023-07-26