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Title
  • en Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain
Creator
Accessrights open access
Rights
Subject
  • Other en Influenza A (H1N1)pdm
  • Other en Vaccine
  • Other en Swine influenza virus
  • NDC 649
Description
  • Abstract en Background: The pandemic 2009 (H1N1) influenza virus has spread throughout the world and is now causing seasonal influenza. To prepare for the emergence of pandemic influenza, we have established a library of virus strains isolated from birds, pigs, and humans in global surveillance studies. Methods: Inactivated whole virus particle (WV) and ether-split (ES) vaccines were prepared from an influenza virus strain, A/swine/Hokkaido/2/1981 (H1N1), from the library and from A/Narita/1/2009 (H1N1) pandemic strain. Each of the vaccines was injected subcutaneously into mice and their potencies were evaluated by challenge with A/Narita/1/2009 (H1N1) virus strain in mice. Results: A/swine/Hokkaido/2/81 (H1N1), which was isolated from the lung of a diseased piglet, was selected on the basis of their antigenicity and growth capacity in embryonated chicken eggs. Two injections of the WV vaccine induced an immune response in mice, decreasing the impact of disease caused by the challenge with A/Narita/1/2009 (H1N1), as did the vaccine prepared from the homologous strain. Conclusion: The WV vaccine prepared from an influenza virus in the library is useful as an emergency vaccine in the early phase of pandemic influenza.
Publisher en BioMed Central
Date
    Issued2013-02-06
Language
  • eng
Resource Type journal article
Version Type VoR
Identifier HDL http://hdl.handle.net/2115/52238
Relation
  • isIdenticalTo DOI https://doi.org/10.1186/1743-422X-10-47
Journal
    • PISSN 1743-422X
      • en Virology Journal
      • Volume Number10 Page Start47
File
    • fulltext VJ10_47.pdf
    • 881.72 KB (application/pdf)
      • Issued2013-02-06
Oaidate 2023-07-26