Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza

Fujikura Daisuke; Chiba Satoko; Muramatsu Daisuke; Kazumata Mika; Nakayama Yosuke; Kawai Taro; Akira Shizuo; Kida Hiroshi; Miyazaki Tadaaki

Title	en Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza
Creator	en Fujikura, Daisuke en Chiba, Satoko en Muramatsu, Daisuke en Kazumata, Mika en Nakayama, Yosuke en Kawai, Taro en Akira, Shizuo en Kida, Hiroshi NRID 1000010109506 en Miyazaki, Tadaaki NRID 1000060272431
Accessrights	open access
Rights	http://creativecommons.org/licenses/by/3.0/ en Creative Commons Attribution 3.0 Unported
Subject	NDC 493
Description	Abstract en Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death. Previously, it has been reported that the hyper induction of gene expression associated with Fas signal is observed in lethal influenza A virus infection. More importantly, it was also reported that functional mutation of the FasL gene protects the host against influenza A virus infection. These observations suggest that induction of FasL signal is functionally associated with the severity of influenza. However, regulation of the induction of FasL or Fas by influenza A virus infection is still unknown. Here, we demonstrated that FasL is induced after the viral infection, and inhibition of the Fas/FasL signal by treatment with a recombinant decoy receptor for FasL (Fas-Fc) increases the survival rate of mice after lethal infection of influenza A virus as well as functional mutation of the FasL gene in gld/gld mice. In addition, the induction level of FasL gene expression in the lung was correlated with the severity of influenza. We also showed that a variety of types of cells in the lung express FasL after the viral infection. Furthermore, type-I interferon induced by the viral infection was shown to be critical for induction of FasL protein expression in the lung. These findings suggested that expression of FasL protein induced by type-I IFN on the lung cell surface is critical to determine the severity of influenza.
Publisher	en Public Library of Science
Date	Issued2013-02-08
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/52234
Relation	isIdenticalTo DOI https://doi.org/10.1371/journal.pone.0055321
Journal	PISSN 1932-6203 en PLoS One Volume Number8 Issue Number2 Page Starte55321
File	fulltext PLoO8-2_e55321.pdf 527.95 KB (application/pdf) Issued2013-02-08
Oaidate	2023-07-26