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Title
  • Mass preparation of oligosaccharides by the hydrolysis of chondroitin sulfate polysaccharides with a subcritical water microreaction system
Creator

Yamada, Shuhei

Matsushima, Keiichiro

Ura, Haruo

Miyamoto, Nobuyuki

Sugahara, Kazuyuki

Subject
  • Other Chondroitin sulfate
  • Other Hydrolysis
  • Other Microreaction system
  • Other Oligosaccharides
  • Other Subcritical water
  • NDC 460
Description
Other
  • The biological functions of chondroitin sulfate (CS) are executed by the interaction of specific oligosaccharide sequences in the polysaccharide chain with effective proteins. Thus, CS oligosaccharides are expected to have pharmacological applications. Furthermore, the demand for CS in health food supplements and medication is growing. However, the absorbency of CS polysaccharides in the digestive system is very low. Since the activity of orally administered CS is expected to increase by depolymerization, industrial production of CS oligosaccharides is required. In this study, hydrolysis with subcritical and super-critical water was applied to the depolymerization of CS for the first time, and hydrolytic conditions for oligosaccharide production were examined. CS oligosaccharides principally containing an N-acetyl-D-galactosamine residue at their reducing ends were successfully obtained. No significant desulfation was found in CS oligosaccharides prepared under optimized conditions. The production of CS oligosaccharides by this method will have a strong influence on the CS-related materials market. (C) 2013 Elsevier Ltd. All rights reserved.
PublisherElsevier
Date Issued 2013-04-19
Languageeng
NIItypejournal article
VersiontypeAM
Identifier URI http://hdl.handle.net/2115/52806
Relation
  • isIdenticalTo PMID 23454651
  • isIdenticalTo DOI https://doi.org/10.1016/j.carres.2013.01.024
Journal
    • ISSN 0008-6215
    • Carbohydrate Research
    371, 16-21
File
Oaidate2019-03-15T05:20:37Z