Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

Tha Khin K.; Terae Satoshi; Nakagawa Shin; Inoue Takeshi; Kitagawa Nobuki; Kako Yuki; Nakato Yasuya; Popy Kawser Akter; Fujima Noriyuki; Zaitsu Yuri; Yoshida Daisuke; Ito Yoichi M.; Miyamoto Tamaki; Koyama Tsukasa; Shirato Hiroki

Title	en Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
Creator	en Tha, Khin K. NRID 1000020451445 en Terae, Satoshi NRID 1000040240634 en Nakagawa, Shin NRID 1000060360905 en Inoue, Takeshi NRID 1000070250438 en Kitagawa, Nobuki NRID 1000080312362 en Kako, Yuki NRID 1000070374444 en Nakato, Yasuya en Popy, Kawser Akter en Fujima, Noriyuki en Zaitsu, Yuri en Yoshida, Daisuke en Ito, Yoichi M. en Miyamoto, Tamaki NRID 1000020271679 en Koyama, Tsukasa NRID 1000010113557 en Shirato, Hiroki NRID 1000020187537
Accessrights	open access
Subject	Other en Fractional anisotropy Other en Mean diffusivity Other en Voxel-based analysis Other en Histogram NDC 492
Description	Abstract en Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Publisher	en Elsevier Ireland Ltd
Date	Issued2013-06-30
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/53150
Relation	isVersionOf DOI https://doi.org/10.1016/j.pscychresns.2012.07.004 PMID 23149032
Journal	PISSN 0925-4927 NCID AA0036432X en Psychiatry Research : Neuroimaging Volume Number212 Issue Number3 Page Start208 Page End215
File	fulltext Manuscript.pdf 926.69 KB (application/pdf) Issued2013-06-30
Oaidate	2023-07-26