| Title |
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en
Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull
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| Creator |
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| Accessrights |
open access |
| Subject |
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Other
en
Unidirectional porous hydroxyapatite (UDPHAp)
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Other
en
Onlay graft
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Other
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Bone augmentation
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Other
en
Recombinant human bone morphogenetic protein-2 (rhBMP-2)
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NDC
497
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| Description |
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Abstract
en
Unidirectional porous hydroxyapatite (UDPHAp) is a material whose microstructure consists of cross-sectional oval pores with a pore diameter in the range of 100-300 mu m that penetrate through the material. UDPHAp has proven suitable for osteogenesis and angiogenesis. The present study was designed to evaluate the osteogenic effect of a newly developed UDPHAp as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat onlay graft model. UDPHAp was implanted beneath the calvarial periosteum of rats to simulate alveolar bone augmentation in a clinical condition. At 2 weeks after implantation, UDPHAp with rhBMP-2 resulted in active bone formation, and the augmented bone was connected directly with the original bone, whereas commercialized porous hydroxyapatite (PHAp) with rhBMP-2 showed little bone formation. These results suggest that UDPHAp in this model is suitable for onlay graft and is an effective biomaterial for the rhBMP-2 delivery system.
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| Publisher |
en
Journal hard tissue biology
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
VoR |
| Identifier |
HDL
http://hdl.handle.net/2115/53343
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| Relation |
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isIdenticalTo
DOI
https://doi.org/10.2485/jhtb.22.337
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| Journal |
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PISSN
1341-7649
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NCID
AA11074332
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en
Journal of hard tissue biology
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Volume Number22
Issue Number3
Page Start337
Page End341
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| File |
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| Oaidate |
2023-07-26 |
