Title |
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Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.
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Creator |
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Accessrights |
open access |
Subject |
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Other
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tenascin-X
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Other
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vascular endothelial growth factor A
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Other
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extracellular matrix
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MeSH
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Animals
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MeSH
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Cell Division/drug effects
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MeSH
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Cell Division/physiology
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MeSH
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Culture Techniques
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MeSH
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Embryo, Mammalian
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MeSH
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Endocardium/cytology
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MeSH
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Endocardium/drug effects
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MeSH
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Endocardium/physiology
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MeSH
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Endothelial Growth Factors/pharmacology
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MeSH
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Endothelial Growth Factors/physiology
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MeSH
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Female
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MeSH
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Humans
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MeSH
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Mice
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MeSH
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Mice, Inbred C57BL
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MeSH
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Mice, Inbred CBA
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MeSH
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Mice, Inbred ICR
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MeSH
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Mice, Knockout
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MeSH
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Pregnancy
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MeSH
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Tenascin/deficiency
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MeSH
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Tenascin/genetics
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MeSH
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Tenascin/pharmacology
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MeSH
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Vascular Endothelial Growth Factor A
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MeSH
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Vascular Endothelial Growth Factor B
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NDC
499
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Description |
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Abstract
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Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo.
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Publisher |
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The Pharmaceutical Society of Japan
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Date |
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Language |
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Resource Type |
journal article |
Version Type |
VoR |
Identifier |
HDL
http://hdl.handle.net/2115/53745
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Relation |
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isIdenticalTo
DOI
https://doi.org/10.1248/bpb.24.1320
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PMID
11725972
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Journal |
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Biological & pharmaceutical bulletin
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Volume Number24
Issue Number11
Page Start1320
Page End1323
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File |
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Oaidate |
2023-07-26 |