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Title
  • en Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.
Creator
    • en Ikuta, Tomoki
    • en Matsumoto, Ken-ichi
Accessrights open access
Subject
  • Other en tenascin-X
  • Other en vascular endothelial growth factor A
  • Other en extracellular matrix
  • MeSH en Animals
  • MeSH en Cell Division/drug effects
  • MeSH en Cell Division/physiology
  • MeSH en Culture Techniques
  • MeSH en Embryo, Mammalian
  • MeSH en Endocardium/cytology
  • MeSH en Endocardium/drug effects
  • MeSH en Endocardium/physiology
  • MeSH en Endothelial Growth Factors/pharmacology
  • MeSH en Endothelial Growth Factors/physiology
  • MeSH en Female
  • MeSH en Humans
  • MeSH en Mice
  • MeSH en Mice, Inbred C57BL
  • MeSH en Mice, Inbred CBA
  • MeSH en Mice, Inbred ICR
  • MeSH en Mice, Knockout
  • MeSH en Pregnancy
  • MeSH en Tenascin/deficiency
  • MeSH en Tenascin/genetics
  • MeSH en Tenascin/pharmacology
  • MeSH en Vascular Endothelial Growth Factor A
  • MeSH en Vascular Endothelial Growth Factor B
  • NDC 499
Description
  • Abstract en Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo.
Publisher en The Pharmaceutical Society of Japan
Date
    Issued2001-11
Language
  • eng
Resource Type journal article
Version Type VoR
Identifier HDL http://hdl.handle.net/2115/53745
Relation
  • isIdenticalTo DOI https://doi.org/10.1248/bpb.24.1320
  • PMID 11725972
Journal
    • PISSN 0918-6158
      • en Biological & pharmaceutical bulletin
      • Volume Number24 Issue Number11 Page Start1320 Page End1323
File
Oaidate 2023-07-26