| Title |
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en
Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis
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| Creator |
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| Accessrights |
open access |
| Rights |
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en
The final publication is available at www.springerlink.com
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| Subject |
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Other
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NETs
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Other
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PTU
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Other
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MPO-ANCA
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Other
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MPO-AAV
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| Description |
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Abstract
en
Neutrophil extracellular traps (NETs) are characterized by the presence of extracellular DNA fibers studded with antimicrobial proteins, including myeloperoxidase (MPO). Although NETs play an important role in the innate immune system, the scattered extracellular enzymes, such as MPO, pose risks to the host. Therefore, NETs are strictly regulated by DNase I in the serum, which prevents them from persisting. Recent studies have demonstrated that dysregulation of NETs could be involved in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. In this review, we interpret the association of disordered NETs with autoimmune diseases, especially propylthiouracil-induced MPO-ANCA-associated vasculitis.
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| Publisher |
en
Springer
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
AM |
| Identifier |
HDL
http://hdl.handle.net/2115/54623
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| Relation |
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isVersionOf
DOI
https://doi.org/10.1007/s10157-012-0738-8
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PMID
23224024
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| Journal |
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PISSN
1342-1751
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EISSN
1437-7799
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en
Clinical and Experimental Nephrology
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Volume Number17
Issue Number5
Page Start631
Page End633
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| File |
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| Oaidate |
2023-07-26 |
