Potency of an inactivated influenza vaccine prepared from A/duck/Hong Kong/960/1980 (H6N2) against a challenge with A/duck/Vietnam/OIE-0033/2012 (H6N2) in mice

Nishi Tatsuya; Sakoda Yoshihiro; Okamatsu Masatoshi; Kida Hiroshi

Title	en Potency of an inactivated influenza vaccine prepared from A/duck/Hong Kong/960/1980 (H6N2) against a challenge with A/duck/Vietnam/OIE-0033/2012 (H6N2) in mice
Creator	en Nishi, Tatsuya en Sakoda, Yoshihiro NRID 1000040333637 en Okamatsu, Masatoshi NRID 1000000507163 en Kida, Hiroshi NRID 1000010109506
Accessrights	open access
Rights	en The final publication is available at link.springer.com
Subject	NDC 649
Description	Abstract en H6 influenza viruses are prevalent in domestic and wild birds in Eurasian countries and have been isolated from pigs and a human. To prepare for an influenza pandemic, we have established an influenza virus library consisting of more than 1,300 influenza virus strains, including 144 combinations of 16 hemagglutinin and 9 neuraminidase subtypes. H6 viruses in the library were classified into Early, Group II, Group III, and W312 sublineages and the North America lineage on the basis of their phylogenetic features. Chicken antisera to A/duck/Hong Kong/960/1980 (H6N2) of the Early sublineage broadly reacted with viruses of different sublineages in a hemagglutinin inhibition test. A whole inactivated virus particle vaccine was prepared from A/duck/Hong Kong/960/1980 (H6N2) which was stocked in the influenza virus library. The potency of this vaccine against A/duck/Vietnam/OIE-0033/2012 (H6N2), which belongs to a different sublineage, was evaluated in mice. The test vaccine was sufficiently potent to induce an immune response that reduced the impact of disease caused by a challenge with A/duck/Vietnam/OIE-0033/2012 (H6N2) in mice. The present results indicate that the whole inactivated virus particle vaccine prepared from a virus strain in the influenza virus library is useful as a vaccine against pandemic influenza.
Publisher	en Springer
Date	Issued2014-10
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/59860
Relation	isVersionOf DOI https://doi.org/10.1007/s00705-014-2107-2 PMID 24824346
Journal	PISSN 0304-8608 NCID AA00548901 en Archives of Virology Volume Number159 Issue Number10 Page Start2567 Page End2574
File	fulltext Arch Virol.159(10)p.2567.pdf 840.39 KB (application/pdf) Issued2014-10
Oaidate	2023-07-26