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Title
  • en Usefulness of C-11-methionine-positron emission tomography for the diagnosis of progressive multifocal leukoencephalopathy
Creator
    • en Shirai, Shinichi
    • en Kano, Takahiro
    • en Shimizu, Yuka
    • en Sasamori, Toru
    • en Sato, Kazunori
    • en Nonaka, Takayuki
    • en Takahashi, Ikuko
    • en Matsushima, Masaaki
    • en Minami, Naoya
    • en Saijo, Masayuki
    • en Hatanaka, Kanako C.
Accessrights open access
Rights
  • en The final publication is available at link.springer.com
Subject
  • Other en Progressive multifocal leukoencephalopathy
  • Other en C-11-methionine-positron emission tomography
  • Other en F-18-fluorodeoxyglucose-positron emission tomography
  • Other en Mefloquine
  • NDC 490
Description
  • Abstract en Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease of the brain caused by the JC virus that occurs mainly in immunocompromised patients. The prognosis is very poor. As the lesion looks like non- specific leukoencephalopathy, making a diagnosis at the early stage is very difficult. We report three PML cases in which there was a mismatch between C-11-methionine-positron emission tomography (MET-PET) uptake and F-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) uptake. All three cases demonstrated the hyper-uptake of MET around the white matter lesions and hypo-uptake of FDG inside the lesions. We speculate that the infection had ended inside the white matter lesions of these patients, while JC virus infection was ongoing around the lesions, resulting in the increase of methionine metabolism, and the glucose metabolism was reduced or intermediate because inflammatory cells infiltrate PML lesions rarely. Two patients who were diagnosed and treated with mefloquine while the JC virus was at a low level in the cerebrospinal fluid are still alive. We suggest the usefulness of MET-PET for the early diagnosis of PML and early treatment with mefloquine.
Publisher en Springer
Date
    Issued2014-12
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/60294
Relation
  • isVersionOf DOI https://doi.org/10.1007/s00415-014-7500-y
  • PMID 25223960
Journal
    • PISSN 0340-5354
      • en Journal of neurology
      • Volume Number261 Issue Number12 Page Start2314 Page End2318
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Oaidate 2023-07-26