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Title
  • en Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats
Creator
Accessrights open access
Rights
  • en The final publication is available at link.springer.com
Subject
  • Other en Dexmedetomidine
  • Other en Synaptic plasticity
  • Other en Long-term potentiation
  • Other en Hippocampus
  • NDC 490
Description
  • Abstract en The aim of this study was to evaluate the effect of dexmedetomidine (DEX) on hippocampal synaptic activity in vivo. The adult rats used for this study received a intraperitoneal bolus injection of 3, 10, 30, or 100 mu g/kg of DEX or an equivalent volume of saline. Electrophysiological recording of the hippocampal CA1 region was initiated 20 min after drug administration. The results are expressed as the percentages of the population spike amplitude measured just before high-frequency stimulation (HFS). The electrophysiological data were analyzed with an area under the curve (AUC) of 10-60 min after HFS. Moreover, to investigate the sedative dose of DEX in rats, we recorded the duration of loss of spontaneous movement after the administration of each dose of DEX. Intraperitoneal administration of DEX at doses of 30 and 100 mu g/kg induced a range of sedative effects. The AUC measurements were significantly lower in the 30 and 100 mu g/kg groups than in those injected with vehicle (vehicle: 8.81 +/- A 0.49, n = 7; DEX 30 A mu g/kg: 6.02 +/- A 0.99, n = 6; DEX 100 A mu g/kg: 5.10 +/- A 0.43, n = 5; P < 0.05). The results of our in vivo study reveal that sedative doses of DEX impaired the induction of hippocampal long-term potentiation (LTP). These findings may signify a causal link between DEX-induced sedative action and hippocampal LTP suppression, providing a better understanding of the mechanisms underlying the DEX-induced sedative and/or amnestic effect.
Publisher en Springer
Date
    Issued2014-12
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/58977
Relation
  • isVersionOf DOI https://doi.org/10.1007/s00540-014-1853-3
  • PMID 24854521
Journal
    • PISSN 0913-8668
      • en Journal of anesthesia
      • Volume Number28 Issue Number6 Page Start828 Page End832
File
Oaidate 2023-07-26