Back

Title
  • en Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report
Creator
Accessrights open access
Rights
  • en ©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
  • http://creativecommons.org/licenses/by-nc-nd/4.0/
  • en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject
  • Other en ANCA-associated vasculitis
  • Other en Cardiac small-vessel involvement
  • Other en Sudden death
  • Other en Autopsy
  • NDC 490
Description
  • Abstract en An 80-year-old Japanese man, who had fever and generalized fatigue not improved by antibiotics, was admitted to our hospital. Laboratory data indicative of renal dysfunction and antineutrophil cytoplasmic antibody (ANCA) in the serum led to the consideration of ANCA-associated vasculitis as a differential diagnosis. However, before the diagnostic confirmation, he was found dead on the bed. Autopsy revealed necrotizing crescentic glomerulonephritis in the kidneys. In addition, necrotizing granulomatous vasculitis with infiltration of multinucleated giant cells and neutrophils but not eosinophils was present in multiple organs. The direct cause of death was presumed as cardiac arrest by lethal arrhythmia because vasculitic lesions were distributed widely in the cardiac walls, acute congestion was observed in the systemic organs, and other causes of death were ruled out. This report presents the unusual manifestation of cardiac small-vessel involvement in ANCA-associated vasculitis related to sudden death.
Publisher en Elsevier
Date
    Issued2015-11
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/63950
Relation
  • isVersionOf DOI https://doi.org/10.1016/j.carpath.2015.07.005
  • PMID 26275759
Journal
    • PISSN 1054-8807
    • NCID AA10993310
      • en Cardiovascular Pathology
      • Volume Number24 Issue Number6 Page Start408 Page End410
File
Oaidate 2023-07-26