Title |
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Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report
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Accessrights |
open access |
Rights |
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©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
- http://creativecommons.org/licenses/by-nc-nd/4.0/
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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Subject |
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Other
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ANCA-associated vasculitis
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Other
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Cardiac small-vessel involvement
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Other
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Sudden death
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Other
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Autopsy
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NDC
490
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Description |
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Abstract
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An 80-year-old Japanese man, who had fever and generalized fatigue not improved by antibiotics, was admitted to our hospital. Laboratory data indicative of renal dysfunction and antineutrophil cytoplasmic antibody (ANCA) in the serum led to the consideration of ANCA-associated vasculitis as a differential diagnosis. However, before the diagnostic confirmation, he was found dead on the bed. Autopsy revealed necrotizing crescentic glomerulonephritis in the kidneys. In addition, necrotizing granulomatous vasculitis with infiltration of multinucleated giant cells and neutrophils but not eosinophils was present in multiple organs. The direct cause of death was presumed as cardiac arrest by lethal arrhythmia because vasculitic lesions were distributed widely in the cardiac walls, acute congestion was observed in the systemic organs, and other causes of death were ruled out. This report presents the unusual manifestation of cardiac small-vessel involvement in ANCA-associated vasculitis related to sudden death.
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Publisher |
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Elsevier
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Date |
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Language |
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Resource Type |
journal article |
Version Type |
AM |
Identifier |
HDL
http://hdl.handle.net/2115/63950
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Relation |
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isVersionOf
DOI
https://doi.org/10.1016/j.carpath.2015.07.005
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PMID
26275759
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Journal |
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PISSN
1054-8807
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NCID
AA10993310
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Cardiovascular Pathology
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Volume Number24
Issue Number6
Page Start408
Page End410
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File |
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Oaidate |
2023-07-26 |