Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

Kozuka Miyuki; Yamane Takuya; Nakano Yoshihisa; Nakagaki Takenori; Ohkubo Iwao; Ariga Hiroyoshi

Title	en Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice
Creator	en Kozuka, Miyuki en Yamane, Takuya en Nakano, Yoshihisa NRID 1000020081581 en Nakagaki, Takenori en Ohkubo, Iwao NRID 1000080152073 en Ariga, Hiroyoshi NRID 1000020143505
Accessrights	open access
Rights	en © 2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject	Other en Aronia juice Other en DPP IV inhibitor Other en Cyanidin 3, 5-diglucoside Other en Antidiabetic effect NDC 499
Description	Abstract en Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5). DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside.
Publisher	en Elsevier
Date	Issued2015-09-25
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/62868
Relation	isVersionOf DOI https://doi.org/10.1016/j.bbrc.2015.08.031 PMID 26296465
Journal	PISSN 0006-291X en Biochemical and biophysical research communications Volume Number465 Issue Number3 Page Start433 Page End436
File	fulltext manuscript.pdf 806.95 KB (application/pdf) Issued2015-09-25
Oaidate	2023-07-26