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Title
  • en Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction
Creator
    • en Takeuchi, Wataru
    • en Suzuki, Atsuro
    • en Morimoto, Yuichi
    • en Ueno, Yuichiro
    • en Kobashi, Keiji
    • en Umegaki, Kikuo
Accessrights open access
Rights
Subject
  • Other en Dual radionuclide
  • Other en Solid-state detector
  • Other en CdTe
  • Other en Scatter correction
  • Other en Crosstalk
  • NDC 490
Description
  • Abstract en Background: A brain single-photon emission computed tomography (SPECT) system using cadmium telluride (CdTe) solid-state detectors was previously developed. This CdTe-SPECT system is suitable for simultaneous dual-radionuclide imaging due to its fine energy resolution (6.6 %). However, the problems of down-scatter and low-energy tail due to the spectral characteristics of a pixelated solid-state detector should be addressed. The objective of this work was to develop a system for simultaneous Tc-99m and I-123 brain studies and evaluate its accuracy. Methods: A scatter correction method using five energy windows (FiveEWs) was developed. The windows are Tc-lower, Tc-main, shared sub-window of Tc-upper and I-lower, I-main, and I-upper. This FiveEW method uses pre-measured responses for primary gamma rays from each radionuclide to compensate for the overestimation of scatter by the triple-energy window method that is used. Two phantom experiments and a healthy volunteer experiment were conducted using the CdTe-SPECT system. A cylindrical phantom and a six-compartment phantom with five different mixtures of Tc-99m and I-123 and a cold one were scanned. The quantitative accuracy was evaluated using 18 regions of interest for each phantom. In the volunteer study, five healthy volunteers were injected with Tc-99m human serum albumin diethylene triamine pentaacetic acid (HSA-D) and scanned (single acquisition). They were then injected with I-123 N-isopropyl-4-iodoamphetamine hydrochloride (IMP) and scanned again (dual acquisition). The counts of the Tc-99m images for the single and dual acquisitions were compared. Results: In the cylindrical phantom experiments, the percentage difference (PD) between the single and dual acquisitions was 5.7 +/- 4.0 % (mean +/- standard deviation). In the six-compartment phantom experiment, the PDs between measured and injected activity for Tc-99m and I-123 were 14.4 +/- 11.0 and 2.3 +/- 1.8 %, respectively. In the volunteer study, the PD between the single and dual acquisitions was 4.5 +/- 3.4 %. Conclusions: This CdTe-SPECT system using the FiveEW method can provide accurate simultaneous dual-radionuclide imaging. A solid-state detector SPECT system using the FiveEW method will permit quantitative simultaneous Tc-99m and I-123 study to become clinically applicable.
Publisher en Springer
Date
    Issued2016-06-29
Language
  • eng
Resource Type journal article
Version Type VoR
Identifier HDL http://hdl.handle.net/2115/62692
Relation
  • isIdenticalTo DOI https://doi.org/10.1186/s40658-016-0147-2
Journal
    • PISSN 2197-7364
      • en EJNMMI physics
      • Volume Number3 Page Start10
File
Oaidate 2023-07-26