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Title
  • en Cerebellar Roles in Self-Timing for Sub- and Supra-Second Intervals
Creator
Accessrights open access
Rights
Subject
  • Other en cognitive function
  • Other en extracellular recording
  • Other en internal time
  • Other en oculomotor
  • Other en primate
  • Other en time reproduction
  • NDC 490
Description
  • Abstract en Previous studies suggest that the cerebellum and basal ganglia are involved in sub-second and supra-second timing, respectively. To test this hypothesis at the cellular level, we examined the activity of single neurons in the cerebellar dentate nucleus in monkeys performing the oculomotor version of the self-timing task. Animals were trained to report the passage of time of 400, 600, 1200, or 2400 ms following a visual cue by making self-initiated memory-guided saccades. We found a sizeable preparatory neuronal activity before self-timed saccades across delay intervals, while the time course of activity correlated with the trial-by-trial variation of saccade latency in different ways depending on the length of the delay intervals. For the shorter delay intervals, the ramping up of neuronal firing rate started just after the visual cue and the rate of rise of neuronal activity correlated with saccade timing. In contrast, for the longest delay (2400 ms), the preparatory activity started late during the delay period, and its onset time correlated with self-timed saccade latency. Because electrical microstimulation applied to the recording sites during saccade preparation advanced self-timed but not reactive saccades, regardless of their directions, the signals in the cerebellum may have a causal role in self-timing. We suggest that the cerebellum may regulate timing in both sub-second and supra-second ranges, although its relative contribution might be greater for sub-second than for supra-second time intervals.
Publisher en Society for Neuroscience
Date
    Issued2017-03-29
Language
  • eng
Resource Type journal article
Version Type VoR
Identifier HDL http://hdl.handle.net/2115/67210
Relation
  • isIdenticalTo DOI https://doi.org/10.1523/JNEUROSCI.2221-16.2017
  • PMID 28242799
Journal
    • PISSN 0270-6474
    • EISSN 1529-2401
      • en The Journal of Neuroscience
      • Volume Number37 Issue Number13 Page Start3511 Page End3522
File
    • fulltext 3511.full.pdf
    • 4.45 MB (application/pdf)
      • Issued2017-03-29
Oaidate 2023-07-26