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Title
  • en Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice
Creator
    • en Yamashita, Maya
    • en Matsumoto, Kurumi
    • en Endo, Tsutomu
    • en Ukibe, Ken
    • en Hosoya, Tomohiro
    • en Matsubara, Yumi
    • en Nakagawa, Hisako
    • en Sakai, Fumihiko
Accessrights open access
Rights
Subject
  • Other en Lactobacillus helveticus SBT2171
  • Other en rheumatoid arthritis
  • Other en collagen-induced arthritis
  • Other en autoantibody production
  • Other en pro-inflammatory cytokines
  • NDC 490
Description
  • Abstract en We recently reported that the intraperitoneal inoculation of Lactobacillus helveticus SBT2171 inhibited the development of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA). In the present study, we evaluated the effect of the oral administration of L. helveticus SBT2171 on CIA development and on the regulation of antigen-specific antibody production and inflammatory immune cells, which have been implicated in the development of RA. Both oral administration and intraperitoneal inoculation of L. helveticus SBT2171 reduced joint swelling, body weight loss, and the serum level of bovine type II collagen (CII)-specific antibodies in the CIA mouse model. The intraperitoneal inoculation also decreased the arthritis incidence, joint damage, and serum level of interleukin (IL)-6. In addition, the numbers of total immune cells, total B cells, germinal center B cells, and CD4+ T cells in the draining lymph nodes were decreased following intraperitoneal inoculation of L. helveticus SBT2171. These findings demonstrate the ability of L. helveticus SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.
Publisher en Frontiers Media
Date
    Issued2017-06-21
Language
  • eng
Resource Type journal article
Version Type VoR
Identifier HDL http://hdl.handle.net/2115/66984
Relation
  • isIdenticalTo DOI https://doi.org/10.3389/fmicb.2017.01159
Journal
    • PISSN 1664-302X
      • en Frontiers in microbiology
      • Volume Number8 Page Start1159
File
Oaidate 2023-07-26