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Title	en Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy
Alternative	en Intestinal metastasis in melanoma
Creator	en Miyazawa, Hajime en Yanagi, Teruki NRID 1000050755973 en Yamaguchi, Yasuyuki en Imafuku, Keisuke en Kitamura, Shinya en Hata, Hiroo NRID 1000090399915 en Uehara, Jiro en Ichikawa, Nobuki NRID 1000050779890 en Ohno, Yosuke en Yoshida, Tadashi NRID 1000070772333 en Homma, Shigenori NRID 1000030533674 en Kawamura, Hideki NRID 1000070645960 en Taketomi, Akinobu NRID 1000070363364 en Shimizu, Hiroshi NRID 1000000146672
Accessrights	open access
Rights	en This is the peer reviewed version of the following article: Miyazawa, H., Yanagi, T., Yamaguchi, Y., Imafuku, K., Kitamura, S., Hata, H., Uehara, J., Ichikawa, N., Ohno, Y., Yoshida, T., Homma, S., Kawamura, H., Taketomi, A. and Shimizu, H. (2017), Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy. J Dermatol, 44: 959-962., which has been published in final form at https://doi.org/10.1111/1346-8138.13825. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Subject	Other en fecal occult blood test Other en intestinal metastasis Other en malignant melanoma Other en nivolumab Other en weight loss NDC 490
Description	Abstract en We report two cases of melanomas in patients who developed intestinal metastasis despite other metastatic sites responding to nivolumab and despite the patients having favorable findings such as vitiligo and normal lactate dehydrogenase. The first case is an 85-year-old man who had been administrated nivolumab for lung/cutaneous metastases. After 22 courses of nivolumab therapy, fever and anorexia had appeared and his bodyweight had decreased. An intussusception on the ileocecal valve was revealed by computed tomography, and emergency surgery revealed metastatic lesions on the colon. The second case is an 87-year-old woman treated with nivolumab for lymph node metastases. After 10 courses, laboratory tests had revealed anemia and positive fecal occult blood. Her bodyweight had decreased. Capsule endoscopy showed scattered tumors and clots, indicating metastases of melanoma. The frequency of symptomatic intestinal metastasis of melanoma is very low. Further, intestinal metastasis of melanoma is difficult to detect through routine examinations. Our cases suggest that fecal occult blood test and decreased bodyweight are indications of intestinal metastases.
Publisher	en John Wiley & Sons
Date	Issued2017-08
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/71133
Relation	isVersionOf DOI https://doi.org/10.1111/1346-8138.13825 PMID 28295515
Journal	PISSN 0385-2407 en Journal of dermatology Volume Number44 Issue Number8 Page Start959 Page End962
File	fulltext JDermatol44_959.pdf 878.74 KB (application/pdf) Issued2017-08
Oaidate	2023-07-26