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Title	en Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system
Creator	en Nishioka, Kentaro NRID 1000080463743 en Prayongrat, Anussara en Ono, Kota en Onodera, Shunsuke en Hashimoto, Takayuki NRID 1000060400678 en Katoh, Norio NRID 1000080572495 en Inoue, Tetsuya NRID 1000010431363 en Kinoshita, Rumiko NRID 1000070507582 en Yasuda, Koichi NRID 1000000431362 en Mori, Takashi en Onimaru, Rikiya NRID 1000080374461 en Shirato, Hiroki NRID 1000020187537 en Shimizu, Shinichi NRID 1000050463724
Accessrights	open access
Rights	http://creativecommons.org/licenses/by-nc/4.0/ en Creative Commons Attribution-NonCommercial 4.0 International
Subject	Other en spot-scanning Other en synchrotron-based Other en proton beam therapy Other en safety Other en toxicity Other en adverse event NDC 490
Description	Abstract en This is a report of a single-institution prospective study evaluating the safety of a spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy (PBT) system. Data collection was performed for 56 patients with 59 treatment sites who received proton beam therapy at Hokkaido University Hospital between March 2014 and July 2015. Forty-one patients were male and 15 were female. The median age was 66 years. The primary lesion sites were prostate (n = 17), bone/soft tissue (n = 10), liver (n = 7), lung (n = 6), central nervous system (n = 5), colon (n = 2), pancreas (n = 2), kidney (n = 2) and others (n = 5). Chemotherapy was administered in 11 patients. The prescribed total dose was from 20 to 76 GyE (Radiobiological equivalent dose, RBE = 1.1), with the median dose of 65 GyE in 4 to 35 fractions. No PBT-related Common Terminology Criteria for Adverse Events Grade 4 or 5 toxicities were observed; the incidence of early PBT-related Grade 4 adverse events was 0% (95% confidence interval 0 to 6.38%). The most common Grade 3 toxicities were hematologic toxicity (12.5%) unlikely to be related to the PBT. One patient developed a left femoral neck fracture (Grade 3) at 14.5 months after PBT for chondrosarcoma of the left pelvis. The pathological findings showed no other malignancies, suggesting that it was possibly related to the PBT. In conclusion, the spot-scanning dedicated, synchrotron-based PBT system is feasible, but further studies on its long-term safety and efficacy are warranted.
Publisher	en Oxford University Press
Date	Issued2018-03
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/70251
Relation	isIdenticalTo DOI https://doi.org/10.1093/jrr/rrx083
Journal	PISSN 0449-3060 en Journal of Radiation Research Volume Number59 Issue Number1 Page Starti63 Page Endi71
File	fulltext rrx083.pdf 1.03 MB (application/pdf) Issued2018-03
Oaidate	2023-07-26