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Title	en Blonanserin suppresses impulsive action in rats
Creator	en Nishitani, Naoya en Sasamori, Hitomi en Ohmura, Yu NRID 1000080597659 en Yoshida, Takayuki NRID 1000060374229 en Yoshioka, Mitsuhiro NRID 1000040182729
Accessrights	metadata only access
Rights	https://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject	Other en Impulsive behavior Other en 1-PP Other en Antipsychotics NDC 490
Description	Abstract en High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs. (C) 2019 The Authors. Production and hosting by Elsevier B.V.
Publisher	en Japanese Pharmacological Society
Date	Issued2019-11
Language	eng
Resource Type	journal article
Version Type	NA
Identifier	HDL http://hdl.handle.net/2115/76506
Relation	isIdenticalTo DOI https://doi.org/10.1016/j.jphs.2019.09.013
Journal	PISSN 1347-8613 en Journal of pharmacological sciences Volume Number141 Issue Number3 Page Start127 Page End130
Oaidate	2023-07-26