一覧に戻る

タイトル	en Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
作成者	en Yamane, Koichiro en Kitamura, Yoshihisa en Yanagida, Takashi en Takata, Kazuyuki en Yanagisawa, Daijiro en Taniguchi, Takashi en Taira, Takahiro en Ariga, Hiroyoshi NRID 1000020143505
アクセス権	open access
権利情報	http://creativecommons.org/licenses/by/3.0/ en Creative Commons Attribution 3.0 Unported
主題	Other en DJ-1 Other en allosteric modulator Other en neuroprotection Other en anti-oxidative response Other en in silico virtual screening Other en in vivo rat brain Other en in vitro neuronal culture NDC 499
内容注記	Abstract en Although a loss-of-function mutation has been identified in familial Parkinson's disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we identified UCP0045037 as a compound that bound to the reduced form of DJ-1 by in silico virtual screening. In this study, we determined the neuroprotective effects of UCP0045037 against focal cerebral ischemia-induced neurodegeneration in rats. Hydrogen peroxide-induced cell death was significantly inhibited by UCP0045037 in both rat mesencephalic dopaminergic neurons and human normal SH-SY5Y cells. In contrast, DJ-1-knockdown SH-SY5Y cells lost the protective activity of UCP0045037. These results suggest that UCP0045037 interacts with endogenous DJ-1 and produces a neuroprotective response.
出版者	en MDPI Publishing
日付	Issued2009-11
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/40077
関連	isIdenticalTo DOI https://doi.org/10.3390/ijms10114789
収録誌情報	PISSN 1422-0067 en International Journal of Molecular Sciences 巻10 号11 開始ページ4789 終了ページ4804
ファイル	fulltext IJMS10-11_4789-4804.pdf 1.04 MB (application/pdf) Issued2009-11
コンテンツ更新日時	2023-07-26