Back

Title	en Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
Creator	en Yamane, Koichiro en Kitamura, Yoshihisa en Yanagida, Takashi en Takata, Kazuyuki en Yanagisawa, Daijiro en Taniguchi, Takashi en Taira, Takahiro en Ariga, Hiroyoshi NRID 1000020143505
Accessrights	open access
Rights	http://creativecommons.org/licenses/by/3.0/ en Creative Commons Attribution 3.0 Unported
Subject	Other en DJ-1 Other en allosteric modulator Other en neuroprotection Other en anti-oxidative response Other en in silico virtual screening Other en in vivo rat brain Other en in vitro neuronal culture NDC 499
Description	Abstract en Although a loss-of-function mutation has been identified in familial Parkinson's disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we identified UCP0045037 as a compound that bound to the reduced form of DJ-1 by in silico virtual screening. In this study, we determined the neuroprotective effects of UCP0045037 against focal cerebral ischemia-induced neurodegeneration in rats. Hydrogen peroxide-induced cell death was significantly inhibited by UCP0045037 in both rat mesencephalic dopaminergic neurons and human normal SH-SY5Y cells. In contrast, DJ-1-knockdown SH-SY5Y cells lost the protective activity of UCP0045037. These results suggest that UCP0045037 interacts with endogenous DJ-1 and produces a neuroprotective response.
Publisher	en MDPI Publishing
Date	Issued2009-11
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/40077
Relation	isIdenticalTo DOI https://doi.org/10.3390/ijms10114789
Journal	PISSN 1422-0067 en International Journal of Molecular Sciences Volume Number10 Issue Number11 Page Start4789 Page End4804
File	fulltext IJMS10-11_4789-4804.pdf 1.04 MB (application/pdf) Issued2009-11
Oaidate	2023-07-26