Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger

Kamishima Tamotsu; Tanimura Kazuhide; Shimizu Masato; Matsuhashi Megumi; Fukae Jun; Kon Yujiro; Hagiwara Hiromi; Narita Akihiro; Aoki Yuko; Kosaka Naoki; Atsumi Tatsuya; Shirato Hiroki; Terae Satoshi

タイトル	en Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger
作成者	en Kamishima, Tamotsu NRID 1000010399868 en Tanimura, Kazuhide en Shimizu, Masato en Matsuhashi, Megumi en Fukae, Jun en Kon, Yujiro en Hagiwara, Hiromi en Narita, Akihiro en Aoki, Yuko en Kosaka, Naoki en Atsumi, Tatsuya NRID 1000020301905 en Shirato, Hiroki NRID 1000020187537 en Terae, Satoshi NRID 1000040240634
アクセス権	open access
権利情報	en The final publication is available at www.springerlink.com
主題	Other en Anti-interleukin 6 receptor antibody Other en Rheumatoid arthritis Other en Quantitative analysis Other en Magnetic resonance imaging Other en Power Doppler ultrasonography NDC 492
内容注記	Abstract en Objectives: To compare quantitative magnetic resonance imaging (MRI) and power Doppler ultrasonography (PDUS) with conventional measures of disease activity in rheumatoid arthritis (RA) patients with the anti-interleukin 6 (anti-IL 6) receptor tocilizumab in terms of responsiveness at a few months to disease activity and ability to predict structural damage at 1 year. Methods: A cohort of patients with RA (n = 29) was evaluated clinically including disease activity score 28 (DAS28) and by semiquantitative (SQ-) and quantitative (Q-) PDUS (bilateral metacarpophalangeal joints) and MRI (one hand and wrist) at initiation of treatment with anti-IL 6 receptor antibody agents and after 2 and 5 months. Conventional radiography for both hands and wrists was performed at baseline and at 12 months. Responsiveness was assessed by standardized response means (SRM). Areas under the curve (AUC) for measures at baseline, 2 and 5 months were correlated with structural damage at one year. Results: Among the laboratory and clinical parameters, DAS28-ESR was the most responsive with a large effect size of SRM. Structural damage progressions for radiography and MR erosion were correlated with AUC of MR bone erosion and Q-PDUS, respectively. Conclusions: In the evaluation of disease activity in RA patients in the first few months after starting anti-IL 6 receptor antibody tocilizumab treatment, the semi-quantitative MR bone erosion score of the hand and quantitative value for power Doppler signal in the finger joint were both responsive and predictive of structural damage progression at 1 year.
出版者	en Springer Berlin / Heidelberg
日付	Issued2011-06
言語	eng
資源タイプ	journal article
出版タイプ	AM
資源識別子	HDL http://hdl.handle.net/2115/49371
関連	isVersionOf DOI https://doi.org/10.1007/s00256-010-1064-4 PMID 21076827
収録誌情報	PISSN 0364-2348 EISSN 1432-2161 en Skeletal Radiology 巻40 号6 開始ページ745 終了ページ755
ファイル	fulltext SR40-6_745-755.pdf 617.43 KB (application/pdf) Issued2011-06
コンテンツ更新日時	2023-07-26