| タイトル |
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en
DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
en
DJ-1
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Other
en
fertilization
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Other
en
endocrine disrupter
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NDC
499
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| 内容注記 |
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Abstract
en
DJ-1 was first identified as an activated ras-dependent oncogene product and was later also found to be an infertility-related protein affected by sperm toxicants such as ornidazole (OR) and epichlorohydrin. These findings suggest that DJ-1 has functions in both somatic cells and sperm. In this study, to determine the relationship between DJ-1 and an endocrine disrupter and to determine the functions of DJ-1 in sperm, in vitro fertilization experiments were carried out using eggs and sperm extracted from mice that had or had not been treated with OR. We found that the amount of DJ-1 in sperm and the efficiency of fertilization decreased with the increasing dose of OR to which the mice were exposed. The addition of an anti-mouse DJ-1 serum to sperm solution before the in vitro fertilization reaction with eggs resulted in a decrease in the efficiency of fertilization to about one-third of that when pre-immune serum was added to sperm solution, indicating that DJ-1 participates in the fertilization.
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| 出版者 |
en
The Pharmaceutical Society of Japan
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
VoR |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/53744
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| 関連 |
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isIdenticalTo
DOI
https://doi.org/10.1248/bpb.25.853
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PMID
12132656
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| 収録誌情報 |
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PISSN
0918-6158
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EISSN
1347-5215
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en
Biological & Pharmaceutical Bulletin
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巻25
号7
開始ページ853
終了ページ856
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
