| タイトル |
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en
Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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en
The final publication is available at link.springer.com
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| 主題 |
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Other
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Dexmedetomidine
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Other
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Synaptic plasticity
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Other
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Long-term potentiation
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Other
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Hippocampus
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NDC
490
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| 内容注記 |
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Abstract
en
The aim of this study was to evaluate the effect of dexmedetomidine (DEX) on hippocampal synaptic activity in vivo. The adult rats used for this study received a intraperitoneal bolus injection of 3, 10, 30, or 100 mu g/kg of DEX or an equivalent volume of saline. Electrophysiological recording of the hippocampal CA1 region was initiated 20 min after drug administration. The results are expressed as the percentages of the population spike amplitude measured just before high-frequency stimulation (HFS). The electrophysiological data were analyzed with an area under the curve (AUC) of 10-60 min after HFS. Moreover, to investigate the sedative dose of DEX in rats, we recorded the duration of loss of spontaneous movement after the administration of each dose of DEX. Intraperitoneal administration of DEX at doses of 30 and 100 mu g/kg induced a range of sedative effects. The AUC measurements were significantly lower in the 30 and 100 mu g/kg groups than in those injected with vehicle (vehicle: 8.81 +/- A 0.49, n = 7; DEX 30 A mu g/kg: 6.02 +/- A 0.99, n = 6; DEX 100 A mu g/kg: 5.10 +/- A 0.43, n = 5; P < 0.05). The results of our in vivo study reveal that sedative doses of DEX impaired the induction of hippocampal long-term potentiation (LTP). These findings may signify a causal link between DEX-induced sedative action and hippocampal LTP suppression, providing a better understanding of the mechanisms underlying the DEX-induced sedative and/or amnestic effect.
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| 出版者 |
en
Springer
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/58977
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1007/s00540-014-1853-3
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PMID
24854521
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| 収録誌情報 |
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en
Journal of anesthesia
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巻28
号6
開始ページ828
終了ページ832
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
