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タイトル
  • en Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus
作成者
    • en Kuroda, Makoto
    • en Marzi, Andrea
    • en Noyori, Osamu
    • en Kajihara, Masahiro
    • en Maruyama, Junki
    • en Matsuno, Keita
    • en Miyamoto, Hiroko
    • en Yoshida, Reiko
    • en Feldmann, Heinz
アクセス権 open access
主題
  • NDC 493
内容注記
  • Abstract en Multiple host molecules are known to be involved in the cellular entry of filoviruses, including Ebola virus (EBOV); T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) have been identified as attachment and fusion receptors, respectively. However, the molecular mechanisms underlying the entry process have not been fully understood. We found that TIM-1 and NPC1 colocalized and interacted in the intracellular vesicles where EBOV glycoprotein (GP)-mediated membrane fusion occurred. Interestingly, a TIM-1-specific monoclonal antibody (MAb), M224/1, prevented GP-mediated membrane fusion and also interfered with the binding of TIM-1 to NPC1, suggesting that the interaction between TIM-1 and NPC1 is important for filovirus membrane fusion. Moreover, MAb M224/1 efficiently inhibited the cellular entry of viruses from all known filovirus species. These data suggest a novel mechanism underlying filovirus membrane fusion and provide a potential cellular target for antiviral compounds that can be universally used against filovirus infections.
出版者 en American Society for Microbiology
日付
    Issued2015-06
言語
  • eng
資源タイプ journal article
出版タイプ VoR
資源識別子 HDL http://hdl.handle.net/2115/59504
関連
  • isIdenticalTo DOI https://doi.org/10.1128/JVI.03156-14
収録誌情報
    • PISSN 0022-538X
    • EISSN 1098-5514
    • NCID AA00708779
      • en Journal of virology
      • 巻89 号12 開始ページ6481 終了ページ6493
ファイル
コンテンツ更新日時 2023-07-26