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タイトル
  • en Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice
作成者
アクセス権 open access
権利情報
  • en © 2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
  • http://creativecommons.org/licenses/by-nc-nd/4.0/
  • en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
主題
  • Other en Aronia juice
  • Other en DPP IV inhibitor
  • Other en Cyanidin 3, 5-diglucoside
  • Other en Antidiabetic effect
  • NDC 499
内容注記
  • Abstract en Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5). DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside.
出版者 en Elsevier
日付
    Issued2015-09-25
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/62868
関連
  • isVersionOf DOI https://doi.org/10.1016/j.bbrc.2015.08.031
  • PMID 26296465
収録誌情報
    • PISSN 0006-291X
      • en Biochemical and biophysical research communications
      • 巻465 号3 開始ページ433 終了ページ436
ファイル
    • fulltext manuscript.pdf
    • 806.95 KB (application/pdf)
      • Issued2015-09-25
コンテンツ更新日時 2023-07-26