Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam

Duc-Huy Chu; Okamatsu Masatoshi; Matsuno Keita; Hiono Takahiro; Ogasawara Kohei; Lam Thanh Nguyen; Long Van Nguyen; Tien Ngoc Nguyen; Thuy Thu Nguyen; Dong Van Pham; Dang Hoang Nguyen; Tho Dang Nguyen; Thanh Long To; Hung Van Nguyen; Kida Hiroshi; Sakoda Yoshihiro

タイトル	en Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam
作成者	en Duc-Huy Chu en Okamatsu, Masatoshi NRID 1000000507163 en Matsuno, Keita NRID 1000040753306 en Hiono, Takahiro en Ogasawara, Kohei en Lam Thanh Nguyen en Long Van Nguyen en Tien Ngoc Nguyen en Thuy Thu Nguyen en Dong Van Pham en Dang Hoang Nguyen en Tho Dang Nguyen en Thanh Long To en Hung Van Nguyen en Kida, Hiroshi NRID 1000010109506 en Sakoda, Yoshihiro NRID 1000040333637
アクセス権	open access
権利情報	en ©2016, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
主題	Other en Avian influenza Other en Antigenic analysis Other en Phylogenetic analysis Other en Live bird market Other en Surveillance NDC 649
内容注記	Abstract en A total of 3,045 environmental samples and oropharyngeal and cloacal swabs from apparently healthy poultry have been collected at three live bird markets (LBMs) at which practices were applied to reduce avian influenza (AI) virus transmission (intervention LBMs) and six conventional LBMs (non-intervention LBMs) in Thua Thien Hue province in 2014 to evaluate the efficacy of the intervention LBMs. The 178 AI viruses, including H3 (19 viruses), H4 (2), H5 (8), H6 (30), H9 (114), and H11 (5), were isolated from domestic ducks, muscovy ducks, chickens, and the environment. The prevalence of AI viruses in intervention LBMs (6.1%; 95% CI: 5.0-7.5) was similar to that in non-intervention LBMs (5.6%; 95% CI: 4.5-6.8; x(2) = 0.532; df = 1; P = 0.53) in the study area. Eight H5N6 highly pathogenic avian influenza (HPAI) viruses were isolated from apparently healthy ducks, muscovy ducks, and an environmental sample in an intervention LBM. The hemagglutinin genes of the H5N6 HPAI viruses belonged to the genetic Glade 23.4.4, and the antigenicity of the H5N6 HPAI viruses differed from the H5N1 HPAI viruses previously circulating in Vietnam. Phylogenetic and antigenic analyses of the H6 and H9 viruses isolated in both types of LBMs revealed that they were closely related to the viruses isolated from domestic birds in China, Group II of H6 viruses and Y280 lineage of H9 viruses. These results indicate that the interventions currently applied in LBMs are insufficient to control AI. A risk analysis should be conducted to identify the key factors contributing to Al virus prevalence in intervention LBMs. (C) 2016 Elsevier B.V. All rights reserved.
出版者	en Elsevier
日付	Issued2016-08-31
言語	eng
資源タイプ	journal article
出版タイプ	AM
資源識別子	HDL http://hdl.handle.net/2115/67102
関連	isVersionOf DOI https://doi.org/10.1016/j.vetmic.2016.07.016 PMID 27527783
収録誌情報	PISSN 0378-1135 EISSN 1873-2542 NCID AA00883633 en Veterinary Microbiology 巻192 開始ページ194 終了ページ203
ファイル	fulltext Manuscript_Table1-5_Fig.1-3.pdf 278.1 KB (application/pdf) Issued2016-08-31 fulltext Suplemental figures.pdf 256.84 KB (application/pdf) Issued2016-08-31
コンテンツ更新日時	2023-07-26