| タイトル |
-
en
Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice
|
| 作成者 |
|
| アクセス権 |
open access |
| 権利情報 |
|
| 主題 |
-
Other
en
Lactobacillus helveticus SBT2171
-
Other
en
rheumatoid arthritis
-
Other
en
collagen-induced arthritis
-
Other
en
autoantibody production
-
Other
en
pro-inflammatory cytokines
-
NDC
490
|
| 内容注記 |
-
Abstract
en
We recently reported that the intraperitoneal inoculation of Lactobacillus helveticus SBT2171 inhibited the development of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA). In the present study, we evaluated the effect of the oral administration of L. helveticus SBT2171 on CIA development and on the regulation of antigen-specific antibody production and inflammatory immune cells, which have been implicated in the development of RA. Both oral administration and intraperitoneal inoculation of L. helveticus SBT2171 reduced joint swelling, body weight loss, and the serum level of bovine type II collagen (CII)-specific antibodies in the CIA mouse model. The intraperitoneal inoculation also decreased the arthritis incidence, joint damage, and serum level of interleukin (IL)-6. In addition, the numbers of total immune cells, total B cells, germinal center B cells, and CD4+ T cells in the draining lymph nodes were decreased following intraperitoneal inoculation of L. helveticus SBT2171. These findings demonstrate the ability of L. helveticus SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.
|
| 出版者 |
en
Frontiers Media
|
| 日付 |
|
| 言語 |
|
| 資源タイプ |
journal article |
| 出版タイプ |
VoR |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/66984
|
| 関連 |
-
isIdenticalTo
DOI
https://doi.org/10.3389/fmicb.2017.01159
|
| 収録誌情報 |
-
-
en
Frontiers in microbiology
-
巻8
開始ページ1159
|
| ファイル |
|
| コンテンツ更新日時 |
2023-07-26 |
