Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy

Miyazawa Hajime; Yanagi Teruki; Yamaguchi Yasuyuki; Imafuku Keisuke; Kitamura Shinya; Hata Hiroo; Uehara Jiro; Ichikawa Nobuki; Ohno Yosuke; Yoshida Tadashi; Homma Shigenori; Kawamura Hideki; Taketomi Akinobu; Shimizu Hiroshi

タイトル	en Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy
その他のタイトル	en Intestinal metastasis in melanoma
作成者	en Miyazawa, Hajime en Yanagi, Teruki NRID 1000050755973 en Yamaguchi, Yasuyuki en Imafuku, Keisuke en Kitamura, Shinya en Hata, Hiroo NRID 1000090399915 en Uehara, Jiro en Ichikawa, Nobuki NRID 1000050779890 en Ohno, Yosuke en Yoshida, Tadashi NRID 1000070772333 en Homma, Shigenori NRID 1000030533674 en Kawamura, Hideki NRID 1000070645960 en Taketomi, Akinobu NRID 1000070363364 en Shimizu, Hiroshi NRID 1000000146672
アクセス権	open access
権利情報	en This is the peer reviewed version of the following article: Miyazawa, H., Yanagi, T., Yamaguchi, Y., Imafuku, K., Kitamura, S., Hata, H., Uehara, J., Ichikawa, N., Ohno, Y., Yoshida, T., Homma, S., Kawamura, H., Taketomi, A. and Shimizu, H. (2017), Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy. J Dermatol, 44: 959-962., which has been published in final form at https://doi.org/10.1111/1346-8138.13825. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
主題	Other en fecal occult blood test Other en intestinal metastasis Other en malignant melanoma Other en nivolumab Other en weight loss NDC 490
内容注記	Abstract en We report two cases of melanomas in patients who developed intestinal metastasis despite other metastatic sites responding to nivolumab and despite the patients having favorable findings such as vitiligo and normal lactate dehydrogenase. The first case is an 85-year-old man who had been administrated nivolumab for lung/cutaneous metastases. After 22 courses of nivolumab therapy, fever and anorexia had appeared and his bodyweight had decreased. An intussusception on the ileocecal valve was revealed by computed tomography, and emergency surgery revealed metastatic lesions on the colon. The second case is an 87-year-old woman treated with nivolumab for lymph node metastases. After 10 courses, laboratory tests had revealed anemia and positive fecal occult blood. Her bodyweight had decreased. Capsule endoscopy showed scattered tumors and clots, indicating metastases of melanoma. The frequency of symptomatic intestinal metastasis of melanoma is very low. Further, intestinal metastasis of melanoma is difficult to detect through routine examinations. Our cases suggest that fecal occult blood test and decreased bodyweight are indications of intestinal metastases.
出版者	en John Wiley & Sons
日付	Issued2017-08
言語	eng
資源タイプ	journal article
出版タイプ	AM
資源識別子	HDL http://hdl.handle.net/2115/71133
関連	isVersionOf DOI https://doi.org/10.1111/1346-8138.13825 PMID 28295515
収録誌情報	PISSN 0385-2407 en Journal of dermatology 巻44 号8 開始ページ959 終了ページ962
ファイル	fulltext JDermatol44_959.pdf 878.74 KB (application/pdf) Issued2017-08
コンテンツ更新日時	2023-07-26