タイトル |
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en
Assessment of impulsivity in adolescent mice : A new training procedure for a 3-choice serial reaction time task
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作成者 |
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アクセス権 |
open access |
権利情報 |
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主題 |
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Other
en
Development
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Other
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C57BL/6N
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Other
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Behavioral inhibition
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Other
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Executive function
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NDC
490
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内容注記 |
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Abstract
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Immaturity in impulse control among adolescents could result in substance abuse, criminal involvement, and suicide. The brains of adolescents and adults are anatomically, neurophysiologically, and pharmacologically different. Therefore, preclinical models of adolescent impulsivity are required to screen drugs for adolescents and elucidate the neural mechanisms underlying age-related differences in impulsivity. The conventional 3- or 5-choice serial reaction time task, which is a widely used task to assess impulsivity in adult rodents, cannot be used for young mice because of two technical problems: impaired growth caused by food restriction and the very long training duration. To overcome these problems, we altered the conventional training process, optimizing the degree of food restriction for young animals and shortening the training duration. We found that almost all basal performance levels were similar between the novel and conventional procedures. We also confirmed the pharmacological validity of our results: the 5-hydroxytryptamine 2C (5-HT2C) receptor agonist Ro60-0175 (0.6 mg/kg, subcutaneous) reduced the occurrence of premature responses, whereas the 5-HT2C receptor antagonist SB242084 (0.5 mg/kg intraperitoneal) increased their occurrence, consistent with results of previous studies using conventional procedures. Furthermore, we detected age-related differences in impulsivity using the novel procedure: adolescent mice were found to be more impulsive than adult mice, congruent with the results of human studies. Thus, the new procedure enables the assessment of impulsivity in adolescent mice and facilitates a better understanding of the neurophysiological/pharmacological properties of adolescents.
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出版者 |
en
Elsevier
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日付 |
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言語 |
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資源タイプ |
journal article |
出版タイプ |
VoR |
資源識別子 |
HDL
http://hdl.handle.net/2115/70904
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関連 |
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isIdenticalTo
DOI
https://doi.org/10.1016/j.bbr.2018.01.014
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requires
HDL
http://hdl.handle.net/2115/70905
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PMID
29355672
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収録誌情報 |
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en
Behavioural brain research
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巻343
開始ページ61
終了ページ70
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ファイル |
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コンテンツ更新日時 |
2023-07-26 |