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Title	en Assessment of impulsivity in adolescent mice : A new training procedure for a 3-choice serial reaction time task
Creator	en Sasamori, Hitomi en Ohmura, Yu NRID 1000080597659 en Kubo, Takuya NRID 1000080344498 en Yoshida, Takayuki NRID 1000060374229 en Yoshioka, Mitsuhiro NRID 1000040182729
Accessrights	open access
Rights	http://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
Subject	Other en Development Other en C57BL/6N Other en Behavioral inhibition Other en Executive function NDC 490
Description	Abstract en Immaturity in impulse control among adolescents could result in substance abuse, criminal involvement, and suicide. The brains of adolescents and adults are anatomically, neurophysiologically, and pharmacologically different. Therefore, preclinical models of adolescent impulsivity are required to screen drugs for adolescents and elucidate the neural mechanisms underlying age-related differences in impulsivity. The conventional 3- or 5-choice serial reaction time task, which is a widely used task to assess impulsivity in adult rodents, cannot be used for young mice because of two technical problems: impaired growth caused by food restriction and the very long training duration. To overcome these problems, we altered the conventional training process, optimizing the degree of food restriction for young animals and shortening the training duration. We found that almost all basal performance levels were similar between the novel and conventional procedures. We also confirmed the pharmacological validity of our results: the 5-hydroxytryptamine 2C (5-HT2C) receptor agonist Ro60-0175 (0.6 mg/kg, subcutaneous) reduced the occurrence of premature responses, whereas the 5-HT2C receptor antagonist SB242084 (0.5 mg/kg intraperitoneal) increased their occurrence, consistent with results of previous studies using conventional procedures. Furthermore, we detected age-related differences in impulsivity using the novel procedure: adolescent mice were found to be more impulsive than adult mice, congruent with the results of human studies. Thus, the new procedure enables the assessment of impulsivity in adolescent mice and facilitates a better understanding of the neurophysiological/pharmacological properties of adolescents.
Publisher	en Elsevier
Date	Issued2018-05-02
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/70904
Relation	isIdenticalTo DOI https://doi.org/10.1016/j.bbr.2018.01.014 requires HDL http://hdl.handle.net/2115/70905 PMID 29355672
Journal	PISSN 0166-4328 en Behavioural brain research Volume Number343 Page Start61 Page End70
File	fulltext 1-s2.0-S0166432817314845-main.pdf 846.25 KB (application/pdf) Issued2018-05-02 fulltext SupplementaryMaterials-program(hierarchical_Bayesian_model)_201802001410750800.txt 796 B (text/plain) Issued2018-05-02 fulltext SupplementaryMaterials-program(target_phase)_201802001410750801.txt 13.66 KB (text/plain) Issued2018-05-02 fulltext SupplementaryMaterials-program(training_phase_in_novel_procedure)_201802001410750802.txt 14.16 KB (text/plain) Issued2018-05-02
Oaidate	2023-07-26