Electrical Storm as an Independent Mortality Risk in Patients with Preserved or Moderately Reduced Left Ventricular Function Results from a Japanese Nationwide Registry

Watanabe Masaya; Yokoshiki Hisashi; Noda Takashi; Yokota Isao; Nitta Takashi; Aizawa Yoshifusa; Ohe Tohru; Kurita Takashi

タイトル	en Electrical Storm as an Independent Mortality Risk in Patients with Preserved or Moderately Reduced Left Ventricular Function Results from a Japanese Nationwide Registry
作成者	en Watanabe, Masaya NRID 1000040632047 en Yokoshiki, Hisashi NRID 1000040360911 en Noda, Takashi en Yokota, Isao NRID 1000020761414 en Nitta, Takashi en Aizawa, Yoshifusa en Ohe, Tohru en Kurita, Takashi
アクセス権	metadata only access
主題	Other en Ventricular tachycardia Other en Non-ischemic heart disease Other en Mortality Other en Implantable cardioverter-defibrillator NDC 490
内容注記	Abstract en Electrical storm (ES), defined by 3 or more occurrences of ventricular arrhythmias within 24 hours, has been shown to be associated with an increased risk of mortality; however, detailed information remains lacking. We aimed to examine the incidence and determinants of ES and its impact on mortality in patients enrolled in the nationwide implantable cardioverter-defibrillator (ICD) registry. We studied 1,256 patients (age 65 +/- 12 years) who had structural heart disease with an ICD. The patients were classified into reduced ejection fraction (EF < 35%; 657 (52%) patients) and preserved or moderately reduced EF (EF >= 35%; 599 (48%) patients). ES occurred in 49 (7%) and 36 (6%) patients in the EF < 35% and EF >= 35% groups (log-rank P = 0.297) during the median follow-up of 2.3 years. ICD with resynchronization therapy was associated with a lower incidence of ES in patients with EF < 35%. Non-ischemic heart disease and diuretics were associated with ES in patients with EF >= 35%. During the follow-up, 10/49 (20%) patients with ES and 80/608 patients (13%) without ES died in patients with EF < 35%, while 7/36 (19%) patients with ES and 38/563 patients (7%) without ES died in those with EF >= 35%. We have created 4 Cox multivariate models. All models showed approximately 2-fold higher hazard ratios in patients with EF >= 35% compared to EF < 35%. Our study showed that the determinants of ES differed between EF < 35% and EF >= 35%. The impact of ES for mortality was numerically higher in EF >= 35% than in EF < 35%, although a significant interaction was not detected.
出版者	en International Heart Journal Association
日付	Issued2021-11-29
言語	eng
資源タイプ	journal article
出版タイプ	NA
資源識別子	HDL http://hdl.handle.net/2115/84302
関連	isIdenticalTo DOI https://doi.org/10.1536/ihj.20-832
収録誌情報	PISSN 1349-2365 en International heart journal 巻62 号6 開始ページ1249 終了ページ1256
コンテンツ更新日時	2023-07-26