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Title
  • en Electrical Storm as an Independent Mortality Risk in Patients with Preserved or Moderately Reduced Left Ventricular Function Results from a Japanese Nationwide Registry
Creator
    • en Noda, Takashi
    • en Nitta, Takashi
    • en Aizawa, Yoshifusa
    • en Ohe, Tohru
    • en Kurita, Takashi
Accessrights metadata only access
Subject
  • Other en Ventricular tachycardia
  • Other en Non-ischemic heart disease
  • Other en Mortality
  • Other en Implantable cardioverter-defibrillator
  • NDC 490
Description
  • Abstract en Electrical storm (ES), defined by 3 or more occurrences of ventricular arrhythmias within 24 hours, has been shown to be associated with an increased risk of mortality; however, detailed information remains lacking. We aimed to examine the incidence and determinants of ES and its impact on mortality in patients enrolled in the nationwide implantable cardioverter-defibrillator (ICD) registry. We studied 1,256 patients (age 65 +/- 12 years) who had structural heart disease with an ICD. The patients were classified into reduced ejection fraction (EF < 35%; 657 (52%) patients) and preserved or moderately reduced EF (EF >= 35%; 599 (48%) patients). ES occurred in 49 (7%) and 36 (6%) patients in the EF < 35% and EF >= 35% groups (log-rank P = 0.297) during the median follow-up of 2.3 years. ICD with resynchronization therapy was associated with a lower incidence of ES in patients with EF < 35%. Non-ischemic heart disease and diuretics were associated with ES in patients with EF >= 35%. During the follow-up, 10/49 (20%) patients with ES and 80/608 patients (13%) without ES died in patients with EF < 35%, while 7/36 (19%) patients with ES and 38/563 patients (7%) without ES died in those with EF >= 35%. We have created 4 Cox multivariate models. All models showed approximately 2-fold higher hazard ratios in patients with EF >= 35% compared to EF < 35%. Our study showed that the determinants of ES differed between EF < 35% and EF >= 35%. The impact of ES for mortality was numerically higher in EF >= 35% than in EF < 35%, although a significant interaction was not detected.
Publisher en International Heart Journal Association
Date
    Issued2021-11-29
Language
  • eng
Resource Type journal article
Version Type NA
Identifier HDL http://hdl.handle.net/2115/84302
Relation
  • isIdenticalTo DOI https://doi.org/10.1536/ihj.20-832
Journal
    • PISSN 1349-2365
      • en International heart journal
      • Volume Number62 Issue Number6 Page Start1249 Page End1256
Oaidate 2023-07-26