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Title
  • en Durability of Aligned Microtubules Dependent on Persistence Length Determines Phase Transition and Pattern Formation in Collective Motion
Creator
    • en Zhou, Hang ja 周, 航
    • en Jung, Wonyeong
    • en Farhana, Tamanna Ishrat
    • en Fujimoto, Kazuya ja 藤本, 和也
    • en Kim, Taeyoon
    • en Yokokawa, Ryuji ja 横川, 隆司
Accessrights open access
Rights
  • en This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'ACS Nano', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.2c05593.
  • en The full-text file will be made open to the public on 13 September 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'
  • en This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
Subject
  • Other en active matter
  • Other en collective motion
  • Other en microtubules
  • Other en persistence length
  • Other en self-organization
Description
  • Abstract en Collective motion is a ubiquitous phenomenon in nature. The collective motion of cytoskeleton filaments results mainly from dynamic collisions and alignments; however, the detailed mechanism of pattern formation still needs to be clarified. In particular, the influence of persistence length, which is a measure of filament flexibility, on collective motion is still unclear and lacks experimental verifications although it is likely to directly affect the orientational flexibility of filaments. Here, we investigated the collective motion of microtubules with different persistence lengths using a microtubule–kinesin motility system. We showed that local interactions between microtubules significantly vary depending on their persistence length. We demonstrated that the bundling of microtubules is enhanced by more durable alignment, rather than by greater likelihood of alignment. An agent-based computational model confirmed that the rigidity-dependent durability of microtubule alignment dominates their collective behavior.
Publisher en American Chemical Society (ACS)
Date
    Available2023-09-13 , Issued2022-09-27
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2433/277228
Relation
  • isVersionOf DOI https://doi.org/10.1021/acsnano.2c05593
  • isIdenticalTo PMID 36098647
fundingReference
  • FunderName ja 日本学術振興会
  • AwardNumber 17H03206 https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17H03206/
  • AwardTitle ja 微小管の曲げ剛性の制御とナノパターニングによる分子機械の実証
  • FunderName ja 日本学術振興会
  • AwardNumber 20H00330 https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20H00330/
  • AwardTitle ja ナノ加工技術により明らかにするモータタンパク質の協働性
Journal
    • PISSN 1936-0851
    • EISSN 1936-086X
      • en ACS Nano
      • Volume Number16 Issue Number9 Page Start14765 Page End14778
File
Oaidate 2023-10-18