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Title
  • ja VEGFとそのレセプターの発現動態が乳腺及び新生仔消化管の分化増殖に及ぼす影響
  • en Effects of VEGF and its receptors on differentiation and proliferation of mammary gland and new born digestive tract
Creator
    • ja 松元, 光春 ja-Kana マツモト, ミツハル en MATSUMOTO, Mitsuharu
    • NRID 1000030157383
Accessrights open access
Subject
  • Other en VEGF
  • Other ja VEGF受容体
  • Other en NOS
  • Other ja 免疫組織化学
  • Other ja 乳腺
  • Other ja 新生仔消化管
  • Other ja 分化増殖
  • Other ja マウス
Description
  • Other ja 2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21580366　研究代表者：松元光春 (鹿児島大学農学部教授)
  • Other ja マウスの正常乳腺におけるVEGFとeNOSおよびnNOSの発現動態、ならびにVEGFR-2の局在を明らかにした。また、ネコの乳腺腫瘍におけるVEGFとiNOSの局在を解析し、グレードとの相関を明らかにした。一方、マウスの消化管では、VEGF、VEGFR-1、VEGFR-2の局在と、生後日齢に伴う発現の変化を明らかにした。乳汁中および胃内乳汁凝固物からVEGFを検出し、VEGF投与によるVEGFR-1の局在の変化を明らかにした。以上のことから、これらの蛋白質が乳腺と新生仔消化管の分化増殖および血管新生に密接に関与していることを示唆した。
  • Other en The effects of VEGF and its receptors on the differentiation and proliferation of mammary gland and new born digestive tract were investigated by immunohistochemistry, histometry and biochemistry. In mouse mammary gland during reproductive cycle, VEGF and NOS (eNOS and bNOS) which generate a free radical gas, NO, expressed strongly in late pregnancy and early lactation. VEGFR-2, one of VEGF receptors, was localized to blood vessel endothelia. In feline mammary tumors, the expressions of VEGF and iNOS were positively correlated with tumor grades. On the other hands, in mouse digestive tract, VEGF was localized to absorptive and glandular epithelium, VEGFR-1 to striated border, VEGFR-2 to blood vessel epithelium. The expressions of these proteins became strongly in advance with dating. After administration of VEGF in the digestive tract, immunoreaction of VEGFR-1 was significantly decreased. Thus, it is suggested that these proteins mentioned above were intimately correlated with the differentiation and proliferation, and angiogenesis in mammary gland and new born digestive tract.
Publisher ja 鹿児島大学 en Kagoshima University
Language
  • jpn
Resource Type research report
Version Type VoR
Identifier HDL http://hdl.handle.net/10232/14724 , URI https://ir.kagoshima-u.ac.jp/records/2498
File
    • fulltext 21580366seika.pdf
    • 199.8 kB (application/pdf)
      • Available2016-10-27
      • Collected2012-05-31
Oaidate 2025-07-08