| Title |
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Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach
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| Creator |
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| Accessrights |
open access |
| Rights |
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en
Copyright (c) 2004 Imperial College Press. The original publication is available at www.worldscinet.com
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| Subject |
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Other
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Attractor ruin
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Other
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chaotic itinerancy
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Other
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Milnor attractor
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Other
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GABAergic interneuron
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Other
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activity-dependent excitatory GABA action
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NDC
481.37
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| Description |
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Abstract
en
The non-classical, but frequently reported behavior of GABA[A] receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity in progress. From the perspective of a dynamical systems approach, such "excitatory" GABAergic responses may serve to temporarily invoke attractor-like memories when extensively activated by, for example, top-down signals as category information or attention, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory structure back to attractor ruins.
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Other
http://www.worldscinet.com/jin/jin.shtml
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| Publisher |
en
Imperial College Press
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
AM |
| Identifier |
HDL
http://hdl.handle.net/2115/588
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| Relation |
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isVersionOf
DOI
https://doi.org/10.1142/S0219635204000506
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| Journal |
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en
Journal of Integrative Neuroscience
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Volume Number3
Issue Number2
Page Start183
Page End205
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| File |
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| Oaidate |
2023-07-26 |
