| Title |
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en
Disordered Expression of HOX Genes in Human Non-Small Cell Lung Cancer
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| Creator |
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| Accessrights |
open access |
| Subject |
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Other
en
Homeobox gene
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Other
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HOX
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Other
en
Real-time RT-PCR
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Other
en
Lung cancer
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NDC
493
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| Description |
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Abstract
en
We hypothesized that the disordered tissue architecture in cancer results from the steps that the cells execute the program designed during ontogeny in a spatiotemporally inappropriate manner. HOX genes are known as master regulators of embryonic morphogenesis, and encode transcription factors which regulate the transcription of the downstream genes to realize the program of body plan. In this study, we quantified the expression levels of 39 HOX genes in 41 human non-small cell lung cancer (non-SCLC) and non-cancerous lung tissues by a comprehensive analysis system based on the realtime RT-PCR method. We found that the expression levels of HOXA1, A5, A10 and C6 in squamous cell carcinoma tissues (and HOXA5 and A10 in adenocarcinoma tissues) were significantly higher than those in the non-cancerous tissues. Comparison of HOX gene expressions between adenocarcinoma and squamous cell carcinoma tissues showed higher expressions of HOXA1, D9, D10 and D11 in squamous cell carcinoma tissues than in adenocarcinoma tissues. Immunohistochemical analysis revealed that HOXA5 and A10 proteins were localized in the cytoplasm of tumor cells in both adenocarcinoma and squamous cell carcinoma tissues. These results suggest that the disordered patterns of HOX gene expressions were involved in not only the development of non-SCLC but also histological diversity such as adenocarcinoma and squamous cell carcinoma.
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| Publisher |
en
PROFESSOR D A SPANDIDOS
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
VoR |
| Identifier |
HDL
http://hdl.handle.net/2115/8484
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| Journal |
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en
ONCOLOGY REPORTS
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Volume Number15
Issue Number4
Page Start797
Page End802
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| File |
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| Oaidate |
2023-07-26 |
