Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma

Yoshioka T.; Miyamoto M.; Cho Y.; Ishikawa K.; Tsuchikawa T.; Kadoya M.; Li L.; Mishra R.; Ichinokawa K.; Shoji Y.; Matsumura Y.; Shichinohe T.; Hirano S.; Shinohara T.; Itoh T.; Kondo S.

Title	en Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma
Creator	en Yoshioka, T. en Miyamoto, M. en Cho, Y. en Ishikawa, K. en Tsuchikawa, T. en Kadoya, M. en Li, L. en Mishra, R. en Ichinokawa, K. en Shoji, Y. en Matsumura, Y. en Shichinohe, T. NRID 1000070374353 en Hirano, S. en Shinohara, T. en Itoh, T. en Kondo, S. NRID 1000030215454
Accessrights	open access
Rights	http://creativecommons.org/licenses/by-nc-nd/3.0/ en Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
Subject	Other en OSCC Other en Foxp3 Other en Treg Other en anti-tumour immunity Other en prognosis NDC 491
Description	Abstract en CD4/8 status has been previously reported to be a critical factor in the prognosis of oesophageal squamous cell carcinoma (OSCC). In the current study, we investigated the effect of regulatory T cells (Treg; Foxp3; lymphocytes) on the status of CD4+ and CD8+ T cells in 122 patients with OSCC. Immunohistochemical analysis of Treg was performed using an antibody against Foxp3. The survival rate for low Foxp3 patients was significantly lower than for high Foxp3 patients (P=0.0028 by log-rank test), but Foxp3 status did not significantly correlate with prognosis in CD4/8(+/+) patients or CD4/8(+/-) or (-/+) patients (P=0.5185 and 0.8479, respectively, by log-rank test). We also found that Foxp3 status correlated with CD4/8 status (P=0.0002 by χ2 test) and that the variance of CD8/CD4 ratio in patients with low Foxp3 was larger than in patients with high Foxp3 (P<0.0001 by F-test). Thus, the results do not support the idea that Treg suppress anti-tumour immunity in patients with OSCC. Rather, the CD8/CD4 ratio and CD4/8 status appear to be critical factors in anti-tumour immunity. Furthermore, Treg numbers correlate with both the CD8/CD4 ratio and the CD4/8 status, suggesting that Treg number is not a factor to predict patient's survival in OSCC.
Publisher	en Nature Publishing Group
Date	Issued2008-04
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/39260
Relation	isIdenticalTo DOI https://doi.org/10.1038/sj.bjc.6604294
Journal	PISSN 0007-0920 EISSN 1532-1827 NCID AA00574355 en British Journal of Cancer Volume Number98 Issue Number7 Page Start1258 Page End1263
File	fulltext 6604294a.pdf 198.44 KB (application/pdf) Issued2008-04
Oaidate	2023-07-26