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Title	en DJ-1 binds to mitochondrial complex I and maintains its activity
Creator	en Hayashi, Takuya en Ishimori, Chikako en Takahashi-Niki, Kazuko NRID 1000050447645 en Taira, Takahiro NRID 1000070197036 en Kim, Yun-chul en Maita, Hiroshi NRID 1000060431318 en Maita, Chinatsu en Ariga, Hiroyoshi NRID 1000020143505 en Iguchi-Ariga, Sanae M. M. NRID 1000090184283
Accessrights	open access
Subject	Other en DJ-1 Other en Mitochondria Other en Parkinson's disease Other en Complex I NDC 493
Description	Abstract en Parkinson's disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD. DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress. The possible mitochondrial function of DJ-1 has been proposed, but its exact function remains unclear. In this study, we found that DJ-1 directly bound to NDUFA4 and ND1, nuclear and mitochondrial DNA-encoding subunits of mitochondrial complex I, respectively, and was co-localized with complex I and that complex I activity was reduced in DJ-1-knockdown NIH3T3 and HEK293 cells. These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity.
Publisher	en Elsevier Inc.
Date	Issued2009-12-18
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/42484
Relation	isVersionOf DOI https://doi.org/10.1016/j.bbrc.2009.10.025 PMID 19822128
Journal	PISSN 0006-291X en Biochemical and Biophysical Research Communications Volume Number390 Issue Number3 Page Start667 Page End672
File	fulltext BBRC390-3_667-672.pdf 922.38 KB (application/pdf) Issued2009-12-18
Oaidate	2023-07-26