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Title
  • DJ-1 binds to mitochondrial complex I and maintains its activity
Creator

Hayashi, Takuya

Ishimori, Chikako

Takahashi-Niki, Kazuko

Taira, Takahiro

Kim, Yun-chul

Maita, Hiroshi

Maita, Chinatsu

Ariga, Hiroyoshi

Iguchi-Ariga, Sanae M. M.

Subject
  • Other DJ-1
  • Other Mitochondria
  • Other Parkinson's disease
  • Other Complex I
  • NDC 493
Description
Other
  • Parkinson's disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD. DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress. The possible mitochondrial function of DJ-1 has been proposed, but its exact function remains unclear. In this study, we found that DJ-1 directly bound to NDUFA4 and ND1, nuclear and mitochondrial DNA-encoding subunits of mitochondrial complex I, respectively, and was co-localized with complex I and that complex I activity was reduced in DJ-1-knockdown NIH3T3 and HEK293 cells. These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity.
PublisherElsevier Inc.
Date Issued 2009-12-18
Languageeng
NIItypejournal article
VersiontypeAM
Identifier URI http://hdl.handle.net/2115/42484
Relation
  • isIdenticalTo PMID 19822128
  • isIdenticalTo DOI https://doi.org/10.1016/j.bbrc.2009.10.025
Journal
    • ISSN 0006-291X
    • Biochemical and Biophysical Research Communications
    390(3), 667-672
File
Oaidate2019-03-15T05:20:33Z